Immunolocalization of lix1 in the regenerating tail of lizard indicates that the protein is mainly present in the nervous tissue.
Immunolocalization
Lix protein
Lizard
Tail regeneration
Journal
Acta histochemica
ISSN: 1618-0372
Titre abrégé: Acta Histochem
Pays: Germany
ID NLM: 0370320
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
19
07
2023
revised:
02
11
2023
accepted:
03
11
2023
medline:
1
12
2023
pubmed:
10
11
2023
entrez:
10
11
2023
Statut:
ppublish
Résumé
Lizard regeneration derives from the re-activation of a number of developmental genes after tail amputation. Among genes with the highest expression, as indicated from the transcriptome, is lix1 which functional role is not known. An antibody that cross-reacts with the lizard Podarcis muralis lix1 has been utilized to detect by immunofluorescence the sites of localization of the protein in the regenerating tail. Lix1-protein is almost exclusively localized in the regenerating spinal cord (ependyma) and nerves growing into the blastema, in sparse blastema cells but is undetectable in other tissues. Since the spinal cord is essential to stimulate tail regeneration it is hypothesized that the lix1 protein is part of the signaling or growing factors produced from the regenerating spinal cord that are needed for tail regeneration of the lizard tail.
Identifiants
pubmed: 37948784
pii: S0065-1281(23)00120-4
doi: 10.1016/j.acthis.2023.152113
pii:
doi:
Substances chimiques
Antibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152113Informations de copyright
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