Neoadjuvant dabrafenib and trametinib for functional organ preservation in recurrent BRAF V600E-mutated papillary thyroid cancer.
Advanced thyroid cancer
BRAF
Dabrafenib
Differentiated thyroid carcinoma
Neoadjuvant kinase inhibitor
Organ conservation
Papillary thyroid carcinoma
Partial laryngectomy
Trametinib
Journal
Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
03
11
2023
accepted:
05
11
2023
medline:
24
11
2023
pubmed:
11
11
2023
entrez:
10
11
2023
Statut:
ppublish
Résumé
To describe the first reported use of neoadjuvant dabrafenib and trametinib specifically to permit organ conservation surgery in locally advanced recurrent differentiated thyroid carcinoma. A patient presented with locally recurrent, radioiodide-resistant DTC with a BRAF V600E mutation invading the laryngotrachea. Definitive treatment would require a total laryngectomy. She was offered neoadjuvant dabrafenib and trametinib prior to surgery. A significant radiographic response permitted partial laryngectomy, enabling preservation of voice, early resumption of oral feeding, and avoidance of permanent tracheostomy. At 9 months, she remained free of disease. Neoadjuvant tyrosine kinase inhibitor treatment prior to definitive surgery for locally-invasive recurrent DTC is a potential approach that may limit the degree of surgery and associated morbidity.
Identifiants
pubmed: 37948895
pii: S1368-8375(23)00321-4
doi: 10.1016/j.oraloncology.2023.106625
pii:
doi:
Substances chimiques
dabrafenib
QGP4HA4G1B
trametinib
33E86K87QN
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Pyridones
0
BRAF protein, human
EC 2.7.11.1
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
106625Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.