Sperm telomere length in male-factor infertility and reproduction.
STL
male-factor infertility
semen analysis
sperm telomere length
telomeres
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
09 Nov 2023
09 Nov 2023
Historique:
received:
27
09
2023
revised:
02
11
2023
accepted:
03
11
2023
pubmed:
11
11
2023
medline:
11
11
2023
entrez:
10
11
2023
Statut:
aheadofprint
Résumé
The underlying reasons for male-factor infertility are often unknown. 30% of all men have unexplained semen analysis abnormalities. Moreover, 15%-40% of infertile men have normal semen analyses. There have been increasing efforts to identify causes and associations that may explain idiopathic male-factor infertility. Telomeres have become an area of considerable interest in the field because of the essential roles they have in cellular division and genome integrity. Research to date most consistently supports that men with infertility have shorter sperm telomere length (STL); however, associations between shorter STL and meaningful reproductive health outcomes are less consistent. There is a major need for additional studies to better identify the role of STL in male reproductive health and use the information to improve the counseling and treatment of couples with idiopathic male-factor infertility.
Identifiants
pubmed: 37949346
pii: S0015-0282(23)01990-8
doi: 10.1016/j.fertnstert.2023.11.001
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests Z.R. has nothing to disclose. H.D. has nothing to disclose. K.F. has nothing to disclose. M.J. has nothing to disclose. K.A. has nothing to disclose. J.H. has nothing to disclose.