PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex.
Humans
HIV-1
/ physiology
Transcriptional Elongation Factors
/ metabolism
Cell Line
Proviruses
/ genetics
T-Lymphocytes
/ metabolism
tat Gene Products, Human Immunodeficiency Virus
/ genetics
Virus Latency
/ genetics
HIV Infections
/ genetics
Protein-Arginine N-Methyltransferases
/ genetics
Intracellular Signaling Peptides and Proteins
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 11 2023
10 11 2023
Historique:
received:
20
05
2023
accepted:
30
10
2023
medline:
13
11
2023
pubmed:
11
11
2023
entrez:
10
11
2023
Statut:
epublish
Résumé
The HIV-1 Tat protein hijacks the Super Elongation Complex (SEC) to stimulate viral transcription and replication. However, the mechanisms underlying Tat activation and inactivation, which mediate HIV-1 productive and latent infection, respectively, remain incompletely understood. Here, through a targeted complementary DNA (cDNA) expression screening, we identify PRMT2 as a key suppressor of Tat activation, thus contributing to proviral latency in multiple cell line latency models and in HIV-1-infected patient CD4
Identifiants
pubmed: 37949879
doi: 10.1038/s41467-023-43060-1
pii: 10.1038/s41467-023-43060-1
pmc: PMC10638354
doi:
Substances chimiques
Transcriptional Elongation Factors
0
tat Gene Products, Human Immunodeficiency Virus
0
AFF4 protein, human
0
PRMT2 protein, human
EC 2.1.1.319
Protein-Arginine N-Methyltransferases
EC 2.1.1.319
Intracellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7274Informations de copyright
© 2023. The Author(s).
Références
Life (Basel). 2021 Nov 19;11(11):
pubmed: 34833139
Genes Dev. 2014 Mar 15;28(6):622-36
pubmed: 24589551
Annu Rev Virol. 2017 Sep 29;4(1):261-285
pubmed: 28715973
J Virol. 1997 May;71(5):4098-102
pubmed: 9094689
Dev Cell. 2018 Apr 23;45(2):262-275.e8
pubmed: 29689199
J Clin Invest. 2001 Jan;107(2):143-51
pubmed: 11160127
Elife. 2013 Mar 05;2:e00327
pubmed: 23471103
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14047-52
pubmed: 12376617
Nat Commun. 2018 Oct 31;9(1):4552
pubmed: 30382083
PLoS Pathog. 2015 Jun 11;11(6):e1004955
pubmed: 26067822
J Leukoc Biol. 2012 Dec;92(6):1147-54
pubmed: 22802445
Cold Spring Harb Symp Quant Biol. 1998;63:371-80
pubmed: 10384302
J Mol Biol. 2022 Jan 15;434(1):167117
pubmed: 34174329
Mol Cell. 2010 Feb 12;37(3):429-37
pubmed: 20159561
PLoS Pathog. 2019 Aug 19;15(8):e1007991
pubmed: 31425551
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E123-31
pubmed: 23251033
Elife. 2018 May 01;7:
pubmed: 29714165
Mol Cell. 2017 Jan 5;65(1):8-24
pubmed: 28061334
Mol Cell. 2010 May 14;38(3):428-38
pubmed: 20471948
Retrovirology. 2014 Jan 15;11:6
pubmed: 24428872
Nat Commun. 2017 May 24;8:15571
pubmed: 28537268
Mol Cell. 2006 Aug 4;23(3):297-305
pubmed: 16885020
Sci Adv. 2020 Apr 01;6(14):eaay4858
pubmed: 32270036
PLoS Pathog. 2019 Jan 15;15(1):e1007498
pubmed: 30645648
Nucleic Acids Res. 2013 Jan 7;41(1):277-87
pubmed: 23087374
Retrovirology. 2009 May 25;6:50
pubmed: 19467159
Nat Immunol. 2023 Feb;24(2):359-370
pubmed: 36536105
Cell Host Microbe. 2010 Mar 18;7(3):234-44
pubmed: 20227666
Elife. 2014 Apr 24;3:e02375
pubmed: 24843025
J Virol. 1990 Apr;64(4):1803-7
pubmed: 2108259
Nat Rev Mol Cell Biol. 2018 Jul;19(7):464-478
pubmed: 29740129
J Virol. 2005 Jan;79(1):124-31
pubmed: 15596808
Nature. 2020 Jan;577(7788):121-126
pubmed: 31853060
Sci Adv. 2023 Mar 10;9(10):eadf2468
pubmed: 36888719
FEBS J. 2017 Jan;284(1):77-96
pubmed: 27879050
Oncogene. 1998 Dec 17;17(24):3093-102
pubmed: 9872325
Cell Host Microbe. 2011 Nov 17;10(5):426-35
pubmed: 22100159
J Virol. 2007 Apr;81(8):4226-34
pubmed: 17267505
Sci Adv. 2020 May 13;6(20):eaaz8411
pubmed: 32426500
Nature. 2018 Jun;558(7709):318-323
pubmed: 29849146
J Biol Chem. 2016 Jul 29;291(31):16240-8
pubmed: 27235396
J Virol. 1998 Feb;72(2):1666-70
pubmed: 9445075
J Virol. 2008 Dec;82(24):12291-303
pubmed: 18829756
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9406-10
pubmed: 3200827
Curr Opin HIV AIDS. 2016 Jul;11(4):394-401
pubmed: 26974532