Expression of insulin-like growth factor binding protein-3 in HELLP syndrome.
Endothelial cell
HELLP syndrome
Inflammatory response
Insulin-like growth factor binding protein-3 (IGFBP-3)
Journal
BMC pregnancy and childbirth
ISSN: 1471-2393
Titre abrégé: BMC Pregnancy Childbirth
Pays: England
ID NLM: 100967799
Informations de publication
Date de publication:
10 Nov 2023
10 Nov 2023
Historique:
received:
18
05
2023
accepted:
17
10
2023
medline:
13
11
2023
pubmed:
11
11
2023
entrez:
11
11
2023
Statut:
epublish
Résumé
To investigate the expression of insulin-like growth factor binding protein-3(IGFBP-3) in HELLP syndrome and its possible role in the pathogenesis of this disease. 1) 87 subjects were enrolled, including 29 patients with HELLP syndrome, 29 patients with pre-eclampsia (PE), and 29 healthy gravidae as control. The levels of IGFBP-3, IGF-1, TGF-β1, and VEGF in maternal and umbilical blood of them were detected using ELISA. Correlation analysis was used to observe the correlation between IGFBP-3 and IGF-1/TGF-β1/VEGF in maternal and umbilical blood, as well as that between maternal serum IGFBP-3 and clinical diagnostic indicators of HELLP syndrome. 2) Human hepatic sinusoid endothelial cells (HLSEC) and human umbilical vein endothelial cells (HUVEC) were cultured with different concentrations of IGFBP-3. After 72 h of culture, cell apoptosis and the normal living cells rate were detected and compared. 1) In both maternal and umbilical blood of HELLP group, levels of IGFBP-3 and TGF-β1 were higher than control and PE group, IGF-1was lower than control group, VEGF was lower than control and PE group. IGFBP-3 in maternal blood was correlated with IGF-1/TGF-β1/ VEGF, while IGFBP-3 in umbilical blood was linked to IGF-1/TGF-β1. In maternal blood, there was a negative correlation between PLT and IGFBP-3, and a positive correlation between ALT/AST/LDH and IGFBP-3. 2) After cultured with IGFBP-3, the total apoptosis rate of either HLSEC or HUVEC was considerably elevated, while the normal living rate was decreased. The expression of IGFBP-3 is elevated in HELLP syndrome, which may subsequently promote cell apoptosis by affecting the expression and function of IGF-1, VEGF, and TGFβ1 in the IGF/PI3K/Akt, TGF-β1/Smad3, and VEGF/eNOS/NO pathways. IGFBP-3 aggravates inflammatory reactions of the vascular endothelium and liver under hypoxia, affects the normal function of cells, and plays a role in the pathogenesis of diseases.
Identifiants
pubmed: 37950229
doi: 10.1186/s12884-023-06074-7
pii: 10.1186/s12884-023-06074-7
pmc: PMC10637003
doi:
Substances chimiques
Insulin-Like Growth Factor Binding Protein 3
0
Insulin-Like Growth Factor I
67763-96-6
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Transforming Growth Factor beta1
0
Vascular Endothelial Growth Factor A
0
IGFBP3 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
778Subventions
Organisme : Suzhou Municipal Health Commission
ID : No. F202045
Organisme : Suzhou Municipal Health Commission
ID : No. F202045
Organisme : Suzhou Municipal Health Commission
ID : No. F202045
Informations de copyright
© 2023. The Author(s).
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