Effects of acute exercise and training status on glucocorticoid-induced leucine zipper (GILZ) expression in human skeletal muscle.
Exercise training
Glucocorticoid
Myopathy
Strength training
Journal
Journal of science and medicine in sport
ISSN: 1878-1861
Titre abrégé: J Sci Med Sport
Pays: Australia
ID NLM: 9812598
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
14
07
2023
revised:
02
10
2023
accepted:
12
10
2023
pubmed:
12
11
2023
medline:
12
11
2023
entrez:
11
11
2023
Statut:
ppublish
Résumé
Interactions between statin therapy and physical exercise complicate effective cardiovascular prevention. Emerging evidence suggests that muscle strain related changes in the expression of the glucocorticoid-induced leucine zipper (GILZ) may be involved. Therefore, we measured GILZ mRNA expression levels in M. vastus lateralis samples of 32 healthy individuals before and after a standardized bout of strength or endurance exercise. Overall, we found a highly significant downregulation of GILZ after exercise training (p < 0.001). Within-subgroup changes were statistically significant only after strength training, supporting the role of muscle (as opposed to cardiocirculatory) strain. If confirmed, this may help fitting training recommendations and medication.
Identifiants
pubmed: 37951824
pii: S1440-2440(23)00428-0
doi: 10.1016/j.jsams.2023.10.007
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
707-710Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interest statement The authors declare that there is no conflict of interest.