Comparison of neuromuscular fatigability amplitude and etiologies between fatigued and non-fatigued cancer patients.
Cancer
Cancer-related fatigue
Force–time asymptote
Neuromuscular fatigability
Twitch interpolation technique
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
received:
09
08
2023
accepted:
25
10
2023
pubmed:
12
11
2023
medline:
12
11
2023
entrez:
12
11
2023
Statut:
ppublish
Résumé
Cancer-related fatigue (CRF) is the most reported side effect of cancer and its treatments. Mechanisms of CRF are multidimensional, including neuromuscular alterations leading to decreased muscle strength and endurance (i.e., fatigability). Recently, exercise fatigability and CRF have been related, while fatigability mechanisms remain unclear. Traditionally, fatigability is assessed from maximal voluntary contractions (MVC) decrease, but some authors hypothesized that the rate of force development (RFD) determined during a rapid contraction could also be an interesting indicator of functional alterations. However, to our knowledge, no study investigated RFD in cancer patients. The purpose of this study was to determine whether RFD, fatigability amplitude, and etiology are different between fatigued and non-fatigued cancer patients. Eighteen participants with cancer, divided in fatigued or non-fatigued groups according their CRF level, completed a 5-min all-out exercise in ankle plantar flexor muscles composed of 62 isometric MVC of 4 s with 1 s rest, to assess fatigability amplitude as the force-time relationship asymptote (F F During treatments, fatigability is higher in fatigued patients; however, the mechanisms of fatigability and RFD alterations are similar in both groups. ClinicalTrials.gov, NCT04391543, May 2020.
Identifiants
pubmed: 37952231
doi: 10.1007/s00421-023-05347-5
pii: 10.1007/s00421-023-05347-5
doi:
Banques de données
ClinicalTrials.gov
['NCT04391543']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1175-1184Subventions
Organisme : Ligue Contre le Cancer
ID : Thesis scholarship
Organisme : Conseil Régional des Pays de la Loire
ID : BIOCARE FActory project
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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