Transcriptomic signature of bacteria exposed to benzalkonium chloride.
Antimicrobial resistance
Gene expression
Multidrug efflux pumps
Quaternary ammonium compounds
RNA-Seq
Stress response
Journal
Research in microbiology
ISSN: 1769-7123
Titre abrégé: Res Microbiol
Pays: France
ID NLM: 8907468
Informations de publication
Date de publication:
10 Nov 2023
10 Nov 2023
Historique:
received:
08
06
2023
revised:
30
10
2023
accepted:
01
11
2023
pubmed:
13
11
2023
medline:
13
11
2023
entrez:
12
11
2023
Statut:
aheadofprint
Résumé
The COVID-19 pandemic has highlighted our reliance on biocides, the increasing prevalence of resistance to biocides is a risk to public health. Bacterial exposure to the biocide, benzalkonium chloride (BAC), resulted in a unique transcriptomic profile, characterised by both a short and long-term response. Differential gene expression was observed in four main areas: motility, membrane composition, proteostasis, and the stress response. A metabolism shift to protect the proteome and the stress response were prioritised suggesting these are main resistance mechanisms. Whereas "well-established" mechanisms, such as biofilm formation, were not found to be differentially expressed after exposure to BAC.
Identifiants
pubmed: 37952705
pii: S0923-2508(23)00126-2
doi: 10.1016/j.resmic.2023.104151
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104151Informations de copyright
Copyright © 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflict of interest to disclose.