Liver Transplantation for Hilar Cholangiocarcinoma.

Humans Klatskin Tumor / surgery Cholangiocarcinoma / surgery Liver Transplantation Bile Ducts, Intrahepatic / surgery Bile Duct Neoplasms / surgery
Hilar cholangiocarcinoma Liver transplantation Neoadjuvant therapy Transplant oncology

Journal

The Surgical clinics of North America
ISSN: 1558-3171
Titre abrégé: Surg Clin North Am
Pays: United States
ID NLM: 0074243

Informations de publication

Date de publication:
Feb 2024
Historique:
medline: 14 11 2023
pubmed: 13 11 2023
entrez: 12 11 2023
Statut: ppublish

Résumé

Hilar cholangiocarcinoma (hCCA) is an infiltrative disease that often presents with locally advanced and/or metastatic disease, with a minority of patients eligible for surgical resection. Select patients with unresectable hCCA, or patients with hCCA in the setting of primary sclerosing cholangitis, with tumors less than 3 cm and no evidence of extrahepatic disease, can be effectively treated with neoadjuvant chemoradiation followed by liver transplantation. Staging laparotomy documenting lack of occult metastatic disease, including a portal lymphadenectomy documenting no nodal metastases, is essential to achieve optimal outcomes. Overall 5 year survival among treated patients is approximately 60%.

Identifiants

DOI: 10.1016/j.suc.2023.09.004 PMID: 37953035
pubmed: 37953035
pii: S0039-6109(23)00149-4
doi: 10.1016/j.suc.2023.09.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

183-196

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The author has nothing to disclose.

Auteurs

Christopher J Sonnenday (CJ)

Department of Surgery, University of Michigan Health, F6686 UH-South, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5296, USA. Electronic address: csonnend@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Liver Transplantation for Hilar Cholangiocarcinoma.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Cholangiocarcinome › Tumeur de Klatskin › Liver Transplantation for Hilar Cholangiocarcinoma.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Cholangiocarcinome › Liver Transplantation for Hilar Cholangiocarcinoma.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation hépatique › Liver Transplantation for Hilar Cholangiocarcinoma.
questionsmedicales.fr › Système digestif › Foie › Conduits biliaires intrahépatiques › Liver Transplantation for Hilar Cholangiocarcinoma.
questionsmedicales.fr › Maladies de l'appareil digestif › Tumeurs de l'appareil digestif › Tumeurs des voies biliaires › Tumeurs des canaux biliaires › Liver Transplantation for Hilar Cholangiocarcinoma.