ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population.
Adipocytes
Adiponectin
Diabetes
Gestational
Polymorphism
Pregnancy
Risk
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
13 Nov 2023
13 Nov 2023
Historique:
received:
09
05
2023
accepted:
06
10
2023
medline:
14
11
2023
pubmed:
13
11
2023
entrez:
12
11
2023
Statut:
epublish
Résumé
Several studies have associated the presence of ADIPOQ gene polymorphisms with insulin resistance, adiponectin levels, and metabolic diseases such as diabetes, although with varying degrees of correlation depending on ethnicity. Here we aim to identify individual's susceptibility to gestational diabetes mellitus (GDM) in the presence of T45G and G276T single nucleotide polymorphisms (SNPs) within the ADIPOQ gene among Filipino pregnant women. A total of 285 pregnant women (95 GDM cases and 190 controls) were included in this study. Two ADIPOQ gene polymorphisms were genotyped using TaqMan assay. Results of SNP genotyping showed no significant differences in the frequencies of TT, TG and GG genotypes of T45G SNP between the GDM and control group [p = 1.0000, 0.6179, 0.5797; OR (95%CI) = 1.030 (0.582-1.874), 1.135 (0.683-1.828), 0.833 (0.481-1.420)]. Similarly, the frequencies of GG, GT, and TT genotypes of G276T SNP were comparable in both groups [p = 0.8002, 1.0000, 0.3466; OR (95%CI) = 1.090 (0.654-1.785), 1.022 (0.616-1.665), 0.433 (0.092-1.698)]. Moreover, although adiponectin levels were significantly decreased in GDM group (p = 0.0196) and have shown substantial negative correlations with FBS, 1-hour OGTT, 2-hour OGTT, and HOMA-IR (p < 0.05), they were not significantly different according to genotypes of T45G and G276T polymorphisms both in GDM and control group. Our results suggest that neither of the two ADIPOQ gene polymorphisms influence adiponectin levels and development of GDM in a Filipino population.
Identifiants
pubmed: 37953238
doi: 10.1186/s12902-023-01479-z
pii: 10.1186/s12902-023-01479-z
pmc: PMC10641948
doi:
Substances chimiques
Adiponectin
0
ADIPOQ protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
248Subventions
Organisme : Philippine Council for Health Research and Development
ID : 18-0200
Informations de copyright
© 2023. The Author(s).
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