Assessment of the therapeutic potential of lutein and beta-carotene nanodispersions in a rat model of fibromyalgia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 11 2023
12 11 2023
Historique:
received:
04
08
2023
accepted:
07
11
2023
medline:
14
11
2023
pubmed:
13
11
2023
entrez:
12
11
2023
Statut:
epublish
Résumé
Fibromyalgia (FM) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, and cognitive impairment. Despite the availability of various treatment options, FM remains a challenging condition to manage. In the present study, we investigated the efficacy of formulated nanodispersions of lutein and beta-carotene in treating FM-related symptoms induced by reserpine in female Wistar rats. Several techniques have been implemented to assess this efficacy at various levels, including biochemical, bioelectrical, and behavioral. Namely, oxidative stress markers, monoamine levels, electrocorticography, pain threshold test, and open field test were conducted on control, FM-induced, and FM-treated groups of animals. Our results provided compelling evidence for the efficacy of carotenoid nanodispersions in treating FM-related symptoms. Specifically, we found that the dual action of the nanodispersion, as both antioxidant and antidepressant, accounted for their beneficial effects in treating FM. With further investigation, nano-carotenoids and particularly nano-lutein could potentially become an effective alternative treatment for patients with FM who do not respond to current treatment options.
Identifiants
pubmed: 37953299
doi: 10.1038/s41598-023-46980-6
pii: 10.1038/s41598-023-46980-6
pmc: PMC10641082
doi:
Substances chimiques
beta Carotene
01YAE03M7J
Lutein
X72A60C9MT
Carotenoids
36-88-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19712Informations de copyright
© 2023. The Author(s).
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