Leptin favors imbalance of antigen-specific CD4
Fel d1
Tfh cells
Tfr cells
Th2/Th9
Treg/Tr-1 cells
leptin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
08
09
2023
accepted:
09
10
2023
medline:
14
11
2023
pubmed:
13
11
2023
entrez:
13
11
2023
Statut:
epublish
Résumé
Obesity can complicate IgE-mediated allergic diseases. In the present study, we aimed to investigate the ability of obesity-related concentrations of leptin to modulate the For this study, plasma and peripheral blood mononuclear cells (PBMC) from 30 cat-allergic patients with mild, moderate and severe respiratory symptoms were obtained. The PBMC cultures were stimulated with Fel d1 antigen (10 µg/mL) in the presence or absence of obesity-related leptin dose (50 ηg/mL). After 6 days, the levels of cytokines and IgE in the supernatants were evaluated by multiplex and ELISA, respectively. The frequency of different non-follicular (CXCR5 Fel d1 induced both IgE production and release of cytokines related to Th2, Th9 and Th17 cell phenotypes. Feld1 was more efficient in increasing the frequency of T
Identifiants
pubmed: 37954580
doi: 10.3389/fimmu.2023.1290740
pmc: PMC10639137
doi:
Substances chimiques
Cytokines
0
Immunoglobulin E
37341-29-0
Interleukin-13
0
Interleukin-4
207137-56-2
Interleukin-5
0
Leptin
0
LEP protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1290740Informations de copyright
Copyright © 2023 Vollmer, Dias, Sales, Sacramento, Silva, Oyamada, Linhares, Gupta, Kasahara and Bento.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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