Two Cases of Frontal Variation of Idiopathic Calvarial Thinning-Therapeutic Effect of Denosumab and Romosozumab.
bifrontal osteodystrophy
bilateral thinning of the frontal bones
denosumab
idiopathic calvarial thinning
osteoporosis
romosozumab
Journal
JCEM case reports
ISSN: 2755-1520
Titre abrégé: JCEM Case Rep
Pays: England
ID NLM: 9918609886906676
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
29
06
2023
medline:
13
11
2023
pubmed:
13
11
2023
entrez:
13
11
2023
Statut:
epublish
Résumé
Idiopathic calvarial thinning is a rare condition that causes progressive, painless thinning of the skull bones without systemic disease. We present 2 cases of idiopathic calvarial thinning involving the bifrontal region. Both patients exhibited forehead depression and had normal biochemical tests except for mild vitamin D deficiency. The first patient received treatment with denosumab for 3 years, showing no further progression of the skull thinning. The second patient was treated with denosumab for 3 years, followed by romosozumab for 1 year, resulting in no further progression and even slight recovery of the skull thickness. These cases demonstrate that idiopathic calvarial thinning can involve the bifrontal region and highlight the favorable treatment and prognosis with denosumab or romosozumab.
Identifiants
pubmed: 37954836
doi: 10.1210/jcemcr/luad122
pii: luad122
pmc: PMC10634628
doi:
Types de publication
Case Reports
Langues
eng
Pagination
luad122Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.
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