Carbene-Catalyzed Direct O-Functionalization of Ketone: Atroposelective Access to Non-
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
24 Nov 2023
24 Nov 2023
Historique:
medline:
13
11
2023
pubmed:
13
11
2023
entrez:
13
11
2023
Statut:
ppublish
Résumé
Disclosed here is NHC-catalyzed direct intermolecular trapping of the ketone oxygen atom with the acyl azolium intermediate. The overall reaction is a dynamic kinetic resolution process that converts ketone to the corresponding enol ester with well-controlled axial chirality. Our reaction eventually affords non-
Identifiants
pubmed: 37955414
doi: 10.1021/acs.orglett.3c03141
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM