Epigenetic Aging is Associated with Measures of Midlife Muscle Volume and Attenuation in CARDIA Study.
GrimAge acceleration
intermuscular adipose tissue
lean muscle attenuation
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837
Informations de publication
Date de publication:
13 Nov 2023
13 Nov 2023
Historique:
received:
13
01
2023
medline:
13
11
2023
pubmed:
13
11
2023
entrez:
13
11
2023
Statut:
aheadofprint
Résumé
GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown. We estimated measures of GAA in 1118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000-01) and 20 (2005-06). Abdominal muscle composition was measured using CT scans at the year 25 (2010-11) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements. In the CARDIA study, each one-year higher GAA was associated with an average 1.1% (95% CI 0.6%, 1.5%) higher intermuscular adipose tissue [IMAT] volume for abdominal muscles. Each one-year higher GAA was associated with an average -0.089 Hounsfield unit (HU) (95% CI -0.146, -0.032) lower lean muscle attenuation and an average -0.049 HU (95% CI -0.092, -0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only. Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.
Sections du résumé
BACKGROUND
BACKGROUND
GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown.
METHODS
METHODS
We estimated measures of GAA in 1118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000-01) and 20 (2005-06). Abdominal muscle composition was measured using CT scans at the year 25 (2010-11) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements.
RESULTS
RESULTS
In the CARDIA study, each one-year higher GAA was associated with an average 1.1% (95% CI 0.6%, 1.5%) higher intermuscular adipose tissue [IMAT] volume for abdominal muscles. Each one-year higher GAA was associated with an average -0.089 Hounsfield unit (HU) (95% CI -0.146, -0.032) lower lean muscle attenuation and an average -0.049 HU (95% CI -0.092, -0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only.
CONCLUSIONS
CONCLUSIONS
Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.
Identifiants
pubmed: 37956337
pii: 7416813
doi: 10.1093/gerona/glad261
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.