Anti-inflammatory labdane diterpenoids from the aerial parts of Leonurus sibiricus.
Anti-inflammation
Labdane diterpenoids
Labiatae
Leonurus sibiricus
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
27
08
2023
revised:
07
11
2023
accepted:
09
11
2023
pubmed:
14
11
2023
medline:
14
11
2023
entrez:
13
11
2023
Statut:
ppublish
Résumé
Eleven undescribed labdane diterpenoids, sibiricusins K-U, and seven known analogues were obtained from the MeOH extract of the aerial parts of Leonurus sibiricus. The structures of the compounds were established by detailed spectroscopic data analysis, single-crystal X-ray diffraction analysis and ECD calculations. Among them, sibiricusins L-N featured a rare α, β-unsaturated-γ-lactam moiety. Fourteen of the isolates were evaluated for their anti-inflammatory effect on the production of NO in LPS-induced RAW264.7 cells through Griess assay. Sibiricusin O displayed the strongest activity with an IC
Identifiants
pubmed: 37956887
pii: S0031-9422(23)00343-6
doi: 10.1016/j.phytochem.2023.113927
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113927Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.