Pharmacological modulation of vascular ageing: A review from VascAgeNet.

Arterial stiffness Dietary supplements Drugs Endothelial dysfunction Pharmacology Vascular ageing

Journal

Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 05 07 2023
revised: 27 10 2023
accepted: 09 11 2023
pubmed: 19 11 2023
medline: 19 11 2023
entrez: 13 11 2023
Statut: ppublish

Résumé

Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.

Identifiants

DOI: 10.1016/j.arr.2023.102122 PMID: 37956927
pubmed: 37956927
pii: S1568-1637(23)00281-7
doi: 10.1016/j.arr.2023.102122
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102122

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Lynn Roth (L)

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium. Electronic address: lynn.roth@uantwerpen.be.

Soner Dogan (S)

Department of Medical Biology, School of Medicine, Yeditepe University, Istanbul, Turkiye.

Bilge Guvenc Tuna (BG)

Department of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkiye.

Tamas Aranyi (T)

Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary; Department of Molecular Biology, Semmelweis University, Budapest, Hungary.

Sonia Benitez (S)

CIBER de Diabetes y enfermedades Metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Cardiovascular Biochemistry, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain.

Maria Borrell-Pages (M)

Cardiovascular Program ICCC, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III, Madrid, Spain.

Perinur Bozaykut (P)

Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkiye.

Guido R Y De Meyer (GRY)

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.

Laurent Duca (L)

UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Team 2 "Matrix Aging and Vascular Remodelling", Université de Reims Champagne Ardenne (URCA), Reims, France.

Nergiz Durmus (N)

Department of Pharmacology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkiye.

Diogo Fonseca (D)

Laboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.

Emil Fraenkel (E)

1st Department of Internal Medicine, University Hospital, Pavol Jozef Šafárik University of Košice, Košice, Slovakia.

Philippe Gillery (P)

UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Team 2 "Matrix Aging and Vascular Remodelling", Université de Reims Champagne Ardenne (URCA), Reims, France; Laboratoire de Biochimie-Pharmacologie-Toxicologie, Centre Hospitalier et Universitaire de Reims, Reims, France.

Alessandro Giudici (A)

Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, the Netherlands; GROW School for Oncology and Reproduction, Maastricht University, the Netherlands.

Stéphane Jaisson (S)

UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Team 2 "Matrix Aging and Vascular Remodelling", Université de Reims Champagne Ardenne (URCA), Reims, France; Laboratoire de Biochimie-Pharmacologie-Toxicologie, Centre Hospitalier et Universitaire de Reims, Reims, France.

Madeleine Johansson (M)

Lund University, Department of Clinical Sciences, Malmo, Sweden.

Josep Julve (J)

CIBER de Diabetes y enfermedades Metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Endocrinology, Diabetes and Nutrition group, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.

Angela K Lucas-Herald (AK)

Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK.

Wim Martinet (W)

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.

Pascal Maurice (P)

UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Team 2 "Matrix Aging and Vascular Remodelling", Université de Reims Champagne Ardenne (URCA), Reims, France.

Barry J McDonnell (BJ)

Centre for Cardiovascular Health and Ageing, Cardiff Metropolitan University, Cardiff, UK.

Emine Nur Ozbek (EN)

Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkiye.

Giacomo Pucci (G)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Christopher J A Pugh (CJA)

Centre for Cardiovascular Health and Ageing, Cardiff Metropolitan University, Cardiff, UK.

Keith D Rochfort (KD)

School of Nursing, Psychotherapy, and Community Health, Dublin City University, Dublin, Ireland.

Anton J M Roks (AJM)

Department of Internal Medicine, Division of Vascular Disease and Pharmacology, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.

Noemi Rotllan (N)

CIBER de Diabetes y enfermedades Metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Pathophysiology of lipid-related diseases, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain.

James Shadiow (J)

School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.

Yahya Sohrabi (Y)

Molecular Cardiology, Dept. of Cardiology I - Coronary and Peripheral Vascular Disease, University Hospital Münster, Westfälische Wilhelms-Universität, 48149 Münster, Germany; Department of Medical Genetics, Third Faculty of Medicine, Charles University, 100 00 Prague, Czechia.

Bart Spronck (B)

Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, the Netherlands; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Australia.

Flora Szeri (F)

Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.

Dimitrios Terentes-Printzios (D)

First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Elif Tunc Aydin (E)

Department of Cardiology, Hospital of Ataturk Training and Research Hospital, Katip Celebi University, Izmir, Turkiye.

Olga Tura-Ceide (O)

Biomedical Research Institute-IDIBGI, Girona, Spain; Department of Pulmonary Medicine, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias, Madrid, Spain.

Eda Ucar (E)

Department of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkiye.

Gunay Yetik-Anacak (G)

Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkiye; Department of Pharmacology, Faculty of Pharmacy, Acıbadem Mehmet Aydinlar University, Istanbul, Turkiye. Electronic address: gunay.anacak@acibadem.edu.tr.

Classifications MeSH