Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2.
Drug repurposing
NTD
Nucleocapsid
RNA binding domain
SARS-CoV-2
Journal
Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
11
10
2023
revised:
07
11
2023
accepted:
08
11
2023
medline:
27
11
2023
pubmed:
14
11
2023
entrez:
13
11
2023
Statut:
ppublish
Résumé
The nucleocapsid (N) protein of SARS-CoV-2 plays a pivotal role in encapsulating the viral genome. Developing antiviral treatments for SARS-CoV-2 is imperative due to the diminishing immunity of the available vaccines. This study targets the RNA-binding site located in the N-terminal domain (NTD) of the N-protein to identify the potential antiviral molecules against SARS-CoV-2. A structure-based repurposing approach identified the twelve high-affinity molecules from FDA-approved drugs, natural products, and the LOPAC
Identifiants
pubmed: 37956938
pii: S0003-9861(23)00319-3
doi: 10.1016/j.abb.2023.109820
pii:
doi:
Substances chimiques
Antiviral Agents
0
RNA
63231-63-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109820Informations de copyright
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