Sorafenib Resistance Contributed by IL7 and MAL2 in Hepatocellular Carcinoma Can Be Overcome by Autophagy-Inducing Stapled Peptides.
IL7
MAL2
autophagy
hepatocellular carcinoma
sorafenib resistance
survival signaling pathways
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Nov 2023
03 Nov 2023
Historique:
received:
13
10
2023
revised:
26
10
2023
accepted:
31
10
2023
medline:
14
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Drug resistance poses a great challenge in systemic therapy for hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms associated with resistance to anti-cancer drugs, such as Sorafenib, remain unclear. In this study, we use transposon insertional mutagenesis to generate Sorafenib-resistant HCC cell lines in order to identify potential drug resistant causative genes. Interleukin 7 (
Identifiants
pubmed: 37958451
pii: cancers15215280
doi: 10.3390/cancers15215280
pmc: PMC10650575
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 82073134
Organisme : The Hong Kong Polytechnic University Research Centre for Chinese Medicine Innovation
ID : 1-BBCT
Organisme : The Hong Kong Polytechnic University/UGC internal funding
ID : 1-ZVST, 1-ZVY7 and 1-WZ52
Organisme : the Research Grants Council of Hong Kong
ID : PolyU 151062/18M, 15103819, 15106421, R5050-18, and AoE/M-09/12
Organisme : Health and Medical Research Fund of Hong Kong
ID : HMRF08191866
Organisme : the Innovation and Technology Fund of Hong Kong
ID : MRP/043/21
Organisme : Shenzhen Basic Research Program of China
ID : JCYJ20170818104619974, JCYJ20210324133803009
Organisme : The State Key Laboratory of Chemical Biology and Drug Discovery
ID : 1-BBX8
Références
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
Cancers (Basel). 2020 Feb 12;12(2):
pubmed: 32059473
Pharmaceuticals (Basel). 2021 May 08;14(5):
pubmed: 34066732
Blood Adv. 2018 Sep 11;2(17):2199-2213
pubmed: 30185437
Nat Genet. 2009 Jun;41(6):753-61
pubmed: 19412179
Hepatology. 1999 Dec;30(6):1434-40
pubmed: 10573522
N Engl J Med. 2008 Jul 24;359(4):378-90
pubmed: 18650514
Cancer Res. 2009 Oct 15;69(20):8150-6
pubmed: 19808965
J Lipid Res. 2020 May;61(5):611-635
pubmed: 33715811
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 32990678
Expert Rev Anticancer Ther. 2009 Apr;9(4):503-9
pubmed: 19374603
Chronic Dis Transl Med. 2018 Sep 17;4(3):148-155
pubmed: 30276361
J Med Chem. 2021 Sep 23;64(18):13475-13486
pubmed: 34506131
Biochem Biophys Res Commun. 2022 Dec 25;636(Pt 1):125-131
pubmed: 36332474
Hepatology. 2011 Mar;53(3):781-90
pubmed: 21374658
Int Rev Immunol. 1998;16(3-4):285-308
pubmed: 9505192
Histol Histopathol. 2004 Jul;19(3):925-33
pubmed: 15168355
Nat Biotechnol. 2009 Mar;27(3):264-74
pubmed: 19234449
N Engl J Med. 2020 Oct 15;383(16):1564-1576
pubmed: 33053285
Lancet Oncol. 2017 Dec;18(12):e731-e741
pubmed: 29208439
Biochem Biophys Rep. 2022 Dec 17;33:101412
pubmed: 36578529
BMC Immunol. 2012 Aug 16;13:46
pubmed: 22897934
Cancers (Basel). 2023 Feb 02;15(3):
pubmed: 36765914
J Neuroimmunol. 2013 May 15;258(1-2):91-5
pubmed: 23528658
BMC Cancer. 2010 Sep 17;10:497
pubmed: 20846453
Nat Commun. 2012 Feb 07;3:662
pubmed: 22314358
Eur J Immunol. 1991 Dec;21(12):2977-85
pubmed: 1684156
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 33393509
Oncol Lett. 2018 Jul;16(1):648-653
pubmed: 29928452
Cancers (Basel). 2019 Jul 15;11(7):
pubmed: 31311187
Nat Genet. 2011 Sep 04;43(10):932-9
pubmed: 21892159
Eur J Cancer. 2009 Mar;45(5):866-73
pubmed: 19136250
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5669-E5678
pubmed: 29866835
Nat Protoc. 2011 Jun;6(6):761-71
pubmed: 21637196
Hepatology. 2013 Jan;57(1):120-30
pubmed: 22899566
Oncol Lett. 2018 Feb;15(2):2625-2630
pubmed: 29434983
Mol Divers. 2022 Oct;26(5):2981-3002
pubmed: 35235141
Onco Targets Ther. 2019 Nov 28;12:10335-10342
pubmed: 31819517
Mol Cancer Res. 2019 Jul;17(7):1582-1593
pubmed: 30975706
J Cell Biol. 2002 Oct 14;159(1):37-44
pubmed: 12370246
J Clin Invest. 2020 Jul 1;130(7):3422-3436
pubmed: 32452837
Biochem Biophys Res Commun. 2021 Feb 19;541:70-77
pubmed: 33482578
Gut. 2019 Jun;68(6):1065-1075
pubmed: 30108162
Int J Clin Exp Pathol. 2014 Feb 15;7(3):870-81
pubmed: 24695377
Acta Pharmacol Sin. 2017 May;38(5):614-622
pubmed: 28344323
Int J Oncol. 2014 Apr;44(4):1349-56
pubmed: 24504262
Int J Mol Sci. 2022 Sep 08;23(18):
pubmed: 36142322
Dig Dis. 2015 Oct;33(6):771-9
pubmed: 26488287
Cancer Genet. 2020 Jul;245:27-34
pubmed: 32559715
J Cancer. 2019 Jun 2;10(12):2745-2753
pubmed: 31258782
Lancet. 2003 Dec 6;362(9399):1907-17
pubmed: 14667750
Cell Rep. 2021 Dec 28;37(13):110160
pubmed: 34965434
Surgery. 2013 Sep;154(3):573-82
pubmed: 23876361
Nat Genet. 2013 Jul;45(7):756-66
pubmed: 23685747
Nat Rev Cancer. 2009 Jun;9(6):400-14
pubmed: 19440234