Serum VEGF and CGRP Biomarkers: Relationships with Pain Intensity, Electric Pain, Pressure Pain Threshold, and Clinical Symptoms in Fibromyalgia-An Observational Study.
biomarkers
calcitonin gene-related peptide
clinical manifestations
fibromyalgia
pain
vascular endothelial growth factor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Oct 2023
24 Oct 2023
Historique:
received:
08
09
2023
revised:
16
10
2023
accepted:
23
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Fibromyalgia (FM) is a multifactorial syndrome, mainly characterized by chronic widespread pain, whose physiopathology is yet to be determined. Reliable biomarkers for FM and how they are associated with the symptomatology have not yet been identified. We aimed to examine the relationships among serum vascular endothelial growth factor (VEGF) and calcitonin gene-related peptide (CGRP) levels with clinical manifestations and pain-related variables in women with FM. We conducted an observational case study with forty-seven women diagnosed with FM. Serum VEGF and CGRP levels were spectrophotometrically analyzed. We used questionnaires to measure the impact of FM and the degree of central sensitization, fatigue, and anxiety. We also assessed pain intensity, electric pain threshold and magnitude, and pressure pain threshold (PPT) in tender points. The linear regression analysis adjusting for age, menopause status, and body mass index showed that serum VEGF levels were significantly associated with the PPTs of non-dominant trapezius (β = 153.418;
Identifiants
pubmed: 37958517
pii: ijms242115533
doi: 10.3390/ijms242115533
pmc: PMC10649295
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Calcitonin Gene-Related Peptide
JHB2QIZ69Z
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondo Europeo de Desarrollo Regional (FEDER) of Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades (Spain)
ID : A-CTS-120-UGR20
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