Mechanism Underlying the Regulation of Mucin Secretion in the Uterus during Pregnancy.
glycosylation
mucins
reproductive hormone
secretory mechanism
uterus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Nov 2023
02 Nov 2023
Historique:
received:
19
09
2023
revised:
23
10
2023
accepted:
28
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
The function of endometrial epithelial cells is to secrete various substances that are rich in growth factors and nutrients. These substances support both embryo implantation and its subsequent development into a fetus. A vast number of mucins are expressed in endometrial epithelial cells, and they play an important role in regulating the processes of embryo implantation, pregnancy, and parturition. Previous studies have shown that mucin forms a mucus layer covering endometrial epithelial cells, which helps resist damage from foreign bacteria and their toxins. Therefore, this article aims to investigate the location of mucins in the endometrium, the mechanism of mucin secretion by the endometrium, and the regulation of mucins in the uterine epithelium by reproductive hormones, as well as the role of mucins in the protection of the epithelium's structure. This research aims to provide a foundational understanding for future studies on the role and mechanism of endometrial mucins throughout the pregnancy cycle.
Identifiants
pubmed: 37958878
pii: ijms242115896
doi: 10.3390/ijms242115896
pmc: PMC10647571
pii:
doi:
Substances chimiques
Mucins
0
Mucin-1
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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