Stress-Mediated Abnormalities in Regional Myocardial Wall Motion in Young Women with a History of Psychological Trauma.
psychological trauma
regional wall motion
risk factors
speckle tracking echocardiography
stress cardiomyopathy
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Oct 2023
24 Oct 2023
Historique:
received:
28
08
2023
revised:
17
10
2023
accepted:
19
10
2023
medline:
14
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Psychosocial stress has been associated with the development and progression of atherosclerotic cardiovascular disease (CVD). Previously, we reported subtle differences in global longitudinal strain in somatically healthy women with a psychiatric diagnosis of borderline personality disorder (BPD). This study aimed to investigate the impact of BPD on segmental myocardial wall motion using speckle tracking echocardiography (STE) analysis. A total of 100 women aged between 18 and 38 years were included in this study. Fifty patients meeting the diagnostic criteria for BPD were recruited from the Department of Psychiatry (LWL-University Hospital Bochum) and compared with fifty age-matched healthy control subjects without previous cardiac disease. Laboratory tests and STE were performed with segmental wall motion analysis. The BPD group had a higher prevalence of risk factors for CVD, with smoking and obesity being predominant, when compared with the control group. Other cardiovascular parameters such as blood pressure, glucose, and cholesterol levels were also elevated, even though not to pathological values. Moreover, in the STE analysis, the BPD group consistently exhibited decreased deformation in nine myocardial wall regions compared with the control group, along with a shift toward higher values in the distribution of peak pathological segments. Additionally, significantly higher values of free thyroxine concentration and thyroid's secretory capacity were observed in the BPD group, despite falling within the (high-) normal range. BPD is associated with chronic stress, classical risk factors, and myocardial wall motion abnormalities. Further exploration is warranted to investigate the relationship between high-normal thyroid metabolism, these risk factors, and myocardial function in BPD patients. Long-term follow-up studies would be valuable in confirming the potential for predicting adverse events.
Sections du résumé
BACKGROUND
BACKGROUND
Psychosocial stress has been associated with the development and progression of atherosclerotic cardiovascular disease (CVD). Previously, we reported subtle differences in global longitudinal strain in somatically healthy women with a psychiatric diagnosis of borderline personality disorder (BPD). This study aimed to investigate the impact of BPD on segmental myocardial wall motion using speckle tracking echocardiography (STE) analysis.
METHODS
METHODS
A total of 100 women aged between 18 and 38 years were included in this study. Fifty patients meeting the diagnostic criteria for BPD were recruited from the Department of Psychiatry (LWL-University Hospital Bochum) and compared with fifty age-matched healthy control subjects without previous cardiac disease. Laboratory tests and STE were performed with segmental wall motion analysis.
RESULTS
RESULTS
The BPD group had a higher prevalence of risk factors for CVD, with smoking and obesity being predominant, when compared with the control group. Other cardiovascular parameters such as blood pressure, glucose, and cholesterol levels were also elevated, even though not to pathological values. Moreover, in the STE analysis, the BPD group consistently exhibited decreased deformation in nine myocardial wall regions compared with the control group, along with a shift toward higher values in the distribution of peak pathological segments. Additionally, significantly higher values of free thyroxine concentration and thyroid's secretory capacity were observed in the BPD group, despite falling within the (high-) normal range.
CONCLUSIONS
CONCLUSIONS
BPD is associated with chronic stress, classical risk factors, and myocardial wall motion abnormalities. Further exploration is warranted to investigate the relationship between high-normal thyroid metabolism, these risk factors, and myocardial function in BPD patients. Long-term follow-up studies would be valuable in confirming the potential for predicting adverse events.
Identifiants
pubmed: 37959168
pii: jcm12216702
doi: 10.3390/jcm12216702
pmc: PMC10647814
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Dr. Georg E. und Marianne Kosing Stiftung
ID : RUB2021
Références
Cardiooncology. 2021 Jan 31;7(1):4
pubmed: 33517910
Eur Heart J. 2006 Dec;27(23):2763-74
pubmed: 17082208
BMC Public Health. 2016 Nov 17;16(1):1124
pubmed: 27852243
J Thyroid Res. 2018 Jul 16;2018:3239197
pubmed: 30174821
Psychosom Med. 2022 Jun 1;84(5):581-587
pubmed: 35412514
Europace. 2015 Oct;17 Suppl 2:ii7-13
pubmed: 26842119
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):33-44
pubmed: 12732221
Echocardiography. 2017 Jun;34(6):835-842
pubmed: 28444773
JACC Cardiovasc Imaging. 2013 Aug;6(8):841-50
pubmed: 23850251
Circulation. 2004 Feb 10;109(5):594-600
pubmed: 14769680
Front Endocrinol (Lausanne). 2016 Jun 09;7:57
pubmed: 27375554
ESC Heart Fail. 2020 Dec;7(6):3726-3737
pubmed: 32902195
Nervenarzt. 2011 Jan;82(1):16-24
pubmed: 21221524
Am J Cardiol. 2012 Dec 15;110(12):1711-6
pubmed: 22975465
Psychosom Med. 2010 Sep;72(7):641-7
pubmed: 20508177
Circulation. 2016 Sep 6;134(10):713-22
pubmed: 27601558
Front Cardiovasc Med. 2022 Aug 15;9:942971
pubmed: 36046184
Psychiatry Res. 2015 Jun 30;227(2-3):253-7
pubmed: 25858801
Echocardiography. 2020 Dec;37(12):2061-2070
pubmed: 33058271
Ann Behav Med. 2017 Dec;51(6):925-930
pubmed: 28417437
J Clin Psychiatry. 2007 Jan;68(1):69-74
pubmed: 17284132
Mol Syst Biol. 2022 Aug;18(8):e10919
pubmed: 35938225
Circulation. 2021 Mar 9;143(10):e763-e783
pubmed: 33486973
Front Endocrinol (Lausanne). 2020 Oct 26;11:542710
pubmed: 33193077
Eur Rev Med Pharmacol Sci. 2022 Jun;26(11):3903-3910
pubmed: 35731059
J Am Coll Cardiol. 2009 Mar 17;53(11):936-46
pubmed: 19281923
N Engl J Med. 2015 Sep 3;373(10):929-38
pubmed: 26332547
Eur Heart J Cardiovasc Imaging. 2015 Jan;16(1):1-11
pubmed: 25525063
Eur Heart J. 2019 Apr 14;40(15):1183-1187
pubmed: 30831580
Eur Heart J Cardiovasc Imaging. 2018 Jun 1;19(6):591-600
pubmed: 29596561
Cardiovasc Ultrasound. 2007 Aug 30;5:27
pubmed: 17760964
Mol Syst Biol. 2016 Nov 8;12(11):886
pubmed: 27875241
Curr Psychiatry Rep. 2019 Jun 4;21(7):51
pubmed: 31161404
Echo Res Pract. 2018 Mar;5(1):27-39
pubmed: 29432198
Cardiovasc Endocrinol Metab. 2020 Dec 24;10(3):182-185
pubmed: 34386720
Mol Psychiatry. 2016 May;21(5):642-9
pubmed: 26033244
Personal Disord. 2013 Apr;4(2):152-9
pubmed: 22686464
J Am Coll Cardiol. 2014 Jul 8;64(1):100-10
pubmed: 24998134
Personal Disord. 2020 Mar;11(2):151-156
pubmed: 31647268
J Cardiovasc Nurs. 2014 Jul;29(4):354-63
pubmed: 23640451
Echocardiography. 2019 Nov;36(11):2026-2032
pubmed: 31682035
Eur J Prev Cardiol. 2022 May 25;29(7):1060-1071
pubmed: 34687540
Eur J Echocardiogr. 2010 Mar;11(2):176-83
pubmed: 19946115
J Intern Med. 2021 May;289(5):675-687
pubmed: 33179374
Crit Care. 2014 Jul 11;18(4):R149
pubmed: 25015102
Am J Cardiol. 2016 Aug 15;118(4):511-9
pubmed: 27324160