Technically Challenging Percutaneous Interventions of Chronic Total Occlusions Are Associated with Enhanced Platelet Activation.
biomarker
chronic total coronary occlusion
coronary intervention
microRNA
platelet activation
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
29 Oct 2023
29 Oct 2023
Historique:
received:
07
09
2023
revised:
14
10
2023
accepted:
25
10
2023
medline:
14
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Percutaneous coronary intervention (PCI) is a frequently performed treatment option for recanalization in patients with chronic total occlusion (CTO). As CTO-PCIs are often complicated and challenging for interventionalists, the stressful and damaging nature of the procedure can be remarkable, thus platelets can be easily activated. Our aim was to investigate the effect of CTO-PCI on platelet activation and the expression of selected circulating microRNAs (miR) of platelet and endothelium origin after CTO-PCI. In this study, 50 subjects after CTO-PCI were enrolled. Blood samples were obtained before PCI, at 2 days and 3-6 months after the procedure to measure the degree of platelet activation and the level of plasma miR-223, miR-181b, and miR-126. Patients were divided based on the characteristics of the intervention. Patients with higher Japanese CTO scores and longer duration of PCI showed significantly elevated platelet P-selectin positivity (
Identifiants
pubmed: 37959293
pii: jcm12216829
doi: 10.3390/jcm12216829
pmc: PMC10648871
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Hungarian Research Fund
ID : FK 135327
Références
Circulation. 2000 Oct 3;102(14):1710-7
pubmed: 11015352
J Am Coll Cardiol. 1997 Apr;29(5):955-63
pubmed: 9120181
Int J Cardiol. 2015 Nov 1;198:222-8
pubmed: 26189193
Circulation. 2011 Apr 26;123(16):1780-4
pubmed: 21518991
Am J Cardiol. 2000 Nov 15;86(10):1057-62
pubmed: 11074199
Nat Struct Mol Biol. 2009 Sep;16(9):961-6
pubmed: 19668211
Int J Mol Sci. 2020 Jan 29;21(3):
pubmed: 32013235
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1516-21
pubmed: 18227515
PLoS One. 2014 Oct 14;9(10):e108468
pubmed: 25313822
Anatol J Cardiol. 2016 Dec;16(12):967-973
pubmed: 27271476
N Engl J Med. 1994 Apr 7;330(14):956-61
pubmed: 8121459
FASEB J. 2016 Sep;30(9):3216-26
pubmed: 27297585
EJIFCC. 2019 Jun 24;30(2):128-145
pubmed: 31263389
Thromb Res. 2022 Sep;217:64-72
pubmed: 35908382
N Engl J Med. 2009 Jan 22;360(4):363-75
pubmed: 19106083
Cardiology. 1999;91(4):236-42
pubmed: 10545679
J Am Coll Cardiol. 2012 Mar 13;59(11):991-7
pubmed: 22402070
Circ Res. 2016 Feb 5;118(3):420-432
pubmed: 26646931
J Invasive Cardiol. 2008 Nov;20(11):571-7
pubmed: 18987395
Nat Rev Cardiol. 2014 Aug;11(8):458-69
pubmed: 24866424
PLoS One. 2018 Jun 11;13(6):e0197890
pubmed: 29889836
Rev Assoc Med Bras (1992). 2020 Oct;66(10):1437-1443
pubmed: 33174940
J Am Heart Assoc. 2018 Jan 12;7(2):
pubmed: 29330258
Coron Artery Dis. 1996 Jul;7(7):529-34
pubmed: 8913671
Platelets. 2010;21(2):147-51
pubmed: 20050761
J Thromb Thrombolysis. 2009 Oct;28(3):366-80
pubmed: 19597766
J Am Coll Cardiol. 1997 Jan;29(1):13-20
pubmed: 8996289
JACC Cardiovasc Interv. 2009 Nov;2(11):1135-41
pubmed: 19926057
J Am Coll Cardiol. 1997 May;29(6):1276-83
pubmed: 9137224
Circulation. 2019 Jul 30;140(5):420-433
pubmed: 31356129
Annu Rev Biochem. 2010;79:351-79
pubmed: 20533884
J Clin Invest. 2012 Jun;122(6):1973-90
pubmed: 22622040
JACC Cardiovasc Interv. 2015 Feb;8(2):245-253
pubmed: 25700746
PLoS One. 2013;8(1):e55168
pubmed: 23383094
JACC Cardiovasc Interv. 2011 Feb;4(2):213-21
pubmed: 21349461
JACC Cardiovasc Interv. 2009 Sep;2(9):834-42
pubmed: 19778771
Biomaterials. 2004 Nov;25(26):5681-703
pubmed: 15147815
Catheter Cardiovasc Interv. 2014 Oct 1;84(4):637-43
pubmed: 24142769
J Am Coll Cardiol. 1992 Apr;19(5):926-35
pubmed: 1552113