Ketogenic Diet Has Moderate Effects on the Fecal Microbiota of Wild-Type Mice.
gut
ketogenic diet
ketosis
microbiome
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
31 Oct 2023
31 Oct 2023
Historique:
received:
28
09
2023
revised:
17
10
2023
accepted:
27
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that has been reported to have neuroprotective effects. The health effects of KD might be linked to an altered gut microbiome, which plays a major role in host health, leading to neuroprotective effects via the gut-brain axis. However, results from different studies, most often based on the 16S rRNA gene and metagenome sequencing, have been inconsistent. In this study, we assessed the effect of a 4-week KD compared to a western diet (WD) on the colonic microbiome of female C57Bl/6J mice by analyzing fecal samples using fluorescence in situ hybridization. Our results showed distinct changes in the total number of gut bacteria following the 4-week KD, in addition to changes in the composition of the microbiome. KD-fed mice showed higher absolute numbers of
Identifiants
pubmed: 37960282
pii: nu15214629
doi: 10.3390/nu15214629
pmc: PMC10648986
pii:
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Neuroprotective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : WE2908/13-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GR1240/20-1
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