Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2
SARS-CoV-2
antiviral
cytotoxicity
drug repurposing
ivermectin
membrane bilayer
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
24 Oct 2023
24 Oct 2023
Historique:
pubmed:
14
11
2023
medline:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Since it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its clinical efficacy. To examine the potential for ivermectin to be repurposed as an antiviral agent, we therefore undertook a series of preclinical studies. Consistent with early reports, ivermectin decreased SARS-CoV-2 viral burden in
Identifiants
pubmed: 37961094
doi: 10.1101/2023.10.23.563088
pmc: PMC10634736
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM021342
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM058055
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122481
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA TR000052
Pays : United States
Déclaration de conflit d'intérêts
Conflicting interests JLD is currently an employee of Agios Pharmaceuticals. RTE is currently an employee of Novartis Pharmaceuticals. The remaining authors hereby declare no conflicting interests pertaining to the material in this manuscript.
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