Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis Throughout the Day.

Chronobiology Circadian Clock Diabetes Diurnal Rhythmicity Feeding Rhythms Glucose Metabolism LC-MS Metabolic Tracing Obesity Ultradian Rhythmicity

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
02 Nov 2023
Historique:
pubmed: 14 11 2023
medline: 14 11 2023
entrez: 14 11 2023
Statut: epublish

Résumé

Rhythmicity is a central feature of behavioral and biological processes including metabolism, however, the mechanisms of metabolite cycling are poorly understood. A robust oscillation in a network of key metabolite pathways downstream of glucose is described in humans, then these pathways mechanistically probed through purpose-built

Identifiants

DOI: 10.1101/2023.10.30.564837 PMID: 37961230 PMC: PMC10634956
pubmed: 37961230
doi: 10.1101/2023.10.30.564837
pmc: PMC10634956
pii:
doi:

Types de publication

Preprint

Langues

eng

Déclaration de conflit d'intérêts

Declaration of Interest The authors declare no competing interests.

Auteurs

Dania M Malik (DM)

Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
These authors contributed equally.

Seth D Rhoades (SD)

Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Fulgens Consulting, LLC, Cambridge, Massachusetts 02142, USA.
These authors contributed equally.

Shirley L Zhang (SL)

Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Arjun Sengupta (A)

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Annika Barber (A)

Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08854, USA.

Paula Haynes (P)

Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Erna Sif Arnadottir (ES)

Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Allan Pack (A)

Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Richard G Kibbey (RG)

Department of Internal Medicine, Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Amita Sehgal (A)

Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Aalim M Weljie (AM)

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Classifications MeSH