CXCL12 regulates coronary artery dominance in diverse populations and links development to disease.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
27 Oct 2023
Historique:
pubmed: 14 11 2023
medline: 14 11 2023
entrez: 14 11 2023
Statut: epublish

Résumé

Mammalian cardiac muscle is supplied with blood by right and left coronary arteries that form branches covering both ventricles of the heart. Whether branches of the right or left coronary arteries wrap around to the inferior side of the left ventricle is variable in humans and termed right or left dominance. Coronary dominance is likely a heritable trait, but its genetic architecture has never been explored. Here, we present the first large-scale multi-ancestry genome-wide association study of dominance in 61,043 participants of the VA Million Veteran Program, including over 10,300 Africans and 4,400 Admixed Americans. Dominance was moderately heritable with ten loci reaching genome wide significance. The most significant mapped to the chemokine

Identifiants

DOI: 10.1101/2023.10.27.23297507 PMID: 37961706 PMC: PMC10635223
pubmed: 37961706
doi: 10.1101/2023.10.27.23297507
pmc: PMC10635223
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCATS NIH HHS
ID : KL2 TR003143
Pays : United States

Auteurs

Pamela E Rios Coronado (PE)

Department of Biology, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-4665-6438

Daniela Zanetti (D)

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
VA Palo Alto Healthcare System, Palo Alto, CA, USA.
Institute of Genetic and Biomedical Research, National Research Council, Cagliari, Sardinia, Italy.
ORCID: 0000-0002-1225-1021

Jiayan Zhou (J)

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
VA Palo Alto Healthcare System, Palo Alto, CA, USA.
ORCID: 0000-0001-5974-087X

Jeffrey A Naftaly (JA)

Department of Biology, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-8981-0063

Pratima Prabala (P)

Department of Biology, Stanford University, Stanford, CA, USA.
ORCID: 0000-0001-6436-6907

Pik Fang Kho (PF)

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
VA Palo Alto Healthcare System, Palo Alto, CA, USA.
ORCID: 0000-0001-7831-6062

Azalia M Martínez Jaimes (AM)

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Department of Biology, Stanford University, Stanford, CA, USA.
ORCID: 0000-0001-9412-6787

Austin T Hilliard (AT)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
ORCID: 0000-0002-1289-4377

Saiju Pyarajan (S)

Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.

Daniel Dochtermann (D)

Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.
ORCID: 0000-0001-9513-5124

Kyong-Mi Chang (KM)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0001-6811-9364

Virginia D Winn (VD)

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-1136-2907

Anca M Pașca (AM)

Department of Pediatrics, Neonatology, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0002-0445-9009

Mary E Plomondon (ME)

Department of Medicine, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
CART Program, VHA Office of Quality and Patient Safety, Washington, DC, USA.
ORCID: 0000-0002-8616-4916

Stephen W Waldo (SW)

Department of Medicine, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
CART Program, VHA Office of Quality and Patient Safety, Washington, DC, USA.
Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA.

Philip S Tsao (PS)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.

Shoa L Clarke (SL)

Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.
VA Palo Alto Healthcare System, Palo Alto, CA, USA.
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0002-6592-1172

Kristy Red-Horse (K)

Department of Biology, Stanford University, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Howard Hughes Medical Institute, Chevy Chase, MD, USA.
ORCID: 0000-0003-1541-601X

Themistocles L Assimes (TL)

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
VA Palo Alto Healthcare System, Palo Alto, CA, USA.
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-2349-0009

Classifications MeSH