Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.

CBP CRL4 DCAF10 E1A IRF3 P300 adenovirus innate immunity virology

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
14 Nov 2023
Historique:
medline: 14 11 2023
pubmed: 14 11 2023
entrez: 14 11 2023
Statut: aheadofprint

Résumé

Inactivation of EP300/CREBB paralogous cellular lysine acetyltransferases (KATs) during the early phase of infection is a consistent feature of DNA viruses. The cell responds by stabilizing transcription factor IRF3 which activates transcription of scores of interferon-stimulated genes (ISGs), inhibiting viral replication. Human respiratory adenoviruses counter this by assembling a CUL4-based ubiquitin ligase complex that polyubiquitinylates RUVBL1 and 2 inducing their proteasomal degradation. This inhibits accumulation of active IRF3 and the expression of anti-viral ISGs, allowing replication of the respiratory HAdVs in the face of inhibition of EP300/CBEBBP KAT activity by the N-terminal region of E1A.

Identifiants

DOI: 10.1128/jvi.00993-23 PMID: 37962355
pubmed: 37962355
doi: 10.1128/jvi.00993-23
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0099323

Auteurs

Nathan R Zemke (NR)

Molecular Biology Institute, University of California, Los Angeles, California, USA.
Department of Cellular and Molecular Medicine, UCSD School of Medicine, La Jolla, California, USA.
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.
ORCID: 0000-0002-6326-5925

Emily Hsu (E)

Molecular Biology Institute, University of California, Los Angeles, California, USA.
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.
Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
ORCID: 0000-0001-5096-0745

William D Barshop (WD)

Thermo Fisher Scientific, San Jose, California, USA.
Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, USC, Los Angeles, California, USA.

Jihui Sha (J)

Thermo Fisher Scientific, San Jose, California, USA.

James A Wohlschlegel (JA)

Molecular Biology Institute, University of California, Los Angeles, California, USA.
Thermo Fisher Scientific, San Jose, California, USA.

Arnold J Berk (AJ)

Molecular Biology Institute, University of California, Los Angeles, California, USA.
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.

Classifications MeSH