Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors.
Myogenesis
Organoids
Pax7
human
ips cells
regenerative medicine
satellite cells
skeletal muscle
stem cells
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 Nov 2023
14 Nov 2023
Historique:
medline:
16
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
In vitro culture systems that structurally model human myogenesis and promote PAX7 Humans contains around 650 skeletal muscles which allow the body to move around and maintain its posture. Skeletal muscles are made up of individual cells that bundle together into highly organized structures. If this group of muscles fail to develop correctly in the embryo and/or fetus, this can lead to muscular disorders that can make it painful and difficult to move
Autres résumés
Type: plain-language-summary
(eng)
Humans contains around 650 skeletal muscles which allow the body to move around and maintain its posture. Skeletal muscles are made up of individual cells that bundle together into highly organized structures. If this group of muscles fail to develop correctly in the embryo and/or fetus, this can lead to muscular disorders that can make it painful and difficult to move
Identifiants
pubmed: 37963071
doi: 10.7554/eLife.87081
pii: 87081
pmc: PMC10645425
doi:
pii:
Substances chimiques
PAX7 Transcription Factor
0
PAX7 protein, human
0
Banques de données
GEO
['GSE147514', 'GSE147457', 'GSE130646', 'GSM2328841']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Duchenne Stiftung, Duchenne Deutschland e.V.,
ID : DFP2018
Organisme : Deutsche Gesellschaft für Muskelkranke
ID : Za1/1
Informations de copyright
© 2023, Mavrommatis et al.
Déclaration de conflit d'intérêts
LM, HJ, UK, GG, MK, MS, OP, DZ, MB, DH, GM, DG, JK, MA, JS, SH, RA, HS, MV, BB, HZ No competing interests declared, JY is partially employed by Next & Bio Inc
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