Nanoparticles based on MIL-101 metal-organic frameworks as efficient carriers of therapeutic

Mice Animals Metal-Organic Frameworks Nuclear Medicine Adenocarcinoma Colonic Neoplasms Radioisotopes Nanoparticles
metal-organic frameworks nanoparticles pharmacokinetics radionuclides rhenium-188

Journal

Nanotechnology
ISSN: 1361-6528
Titre abrégé: Nanotechnology
Pays: England
ID NLM: 101241272

Informations de publication

Date de publication:
01 Dec 2023
Historique:
received: 28 08 2023
accepted: 14 11 2023
medline: 4 12 2023
pubmed: 14 11 2023
entrez: 14 11 2023
Statut: epublish

Résumé

Nuclear medicine presents one of the most promising modalities for efficient non-invasive treatment of a variety of cancers, but the application of radionuclides in cancer therapy and diagnostics is severely limited by their nonspecific tissue accumulation and poor biocompatibility. Here, we explore the use of nanosized metal-organic frameworks (MOFs) as carriers of radionuclides to order to improve their delivery to tumour. To demonstrate the concept, we prepared polymer-coated MIL-101(Cr)-NH

Identifiants

DOI: 10.1088/1361-6528/ad0c74 PMID: 37963406
pubmed: 37963406
doi: 10.1088/1361-6528/ad0c74
doi:

Substances chimiques

MIL-101 0
Metal-Organic Frameworks 0
Radioisotopes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023 IOP Publishing Ltd.

Auteurs

Iaroslav B Belyaev (IB)

National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Institute for Physics and Engineering in Biomedicine (PhysBio), Moscow 115409, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.

Ivan V Zelepukin (IV)

National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Institute for Physics and Engineering in Biomedicine (PhysBio), Moscow 115409, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
ORCID: 0000-0003-0209-2116

Victoria K Tishchenko (VK)

A. Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.

Vasiliy M Petriev (VM)

National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Institute for Physics and Engineering in Biomedicine (PhysBio), Moscow 115409, Russia.
A. Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.

Daria B Trushina (DB)

Federal Research Center 'Crystallography and Photonics', Russian Academy of Sciences, Moscow 119333, Russia.
Sechenov First Moscow State Medical University (Sechenov University), 119991, Moscow, Russia.

Sergey M Klimentov (SM)

National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Institute for Physics and Engineering in Biomedicine (PhysBio), Moscow 115409, Russia.

Irina N Zavestovskaya (IN)

National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Institute for Physics and Engineering in Biomedicine (PhysBio), Moscow 115409, Russia.

Sergey A Ivanov (SA)

A. Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.

Andrey D Kaprin (AD)

A. Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.

Sergey M Deyev (SM)

National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Institute for Physics and Engineering in Biomedicine (PhysBio), Moscow 115409, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Sechenov First Moscow State Medical University (Sechenov University), 119991, Moscow, Russia.
Kazan Federal University, Institute of Fundamental Medicine and Biology, 420008, Kazan, Russia.

Andrei V Kabashin (AV)

Aix Marseille University, CNRS, LP3, Campus de Luminy, Case 917, F-13288, Marseille, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Nanoparticles based on MIL-101 metal-organic...
questionsmedicales.fr › Eucaryotes › Animaux › Nanoparticles based on MIL-101 metal-organic...
questionsmedicales.fr › Structures macromoléculaires › Réseaux organométalliques › Nanoparticles based on MIL-101 metal-organic...
questionsmedicales.fr › Professions de santé › Médecine › Radiologie › Médecine nucléaire › Nanoparticles based on MIL-101 metal-organic...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Nanoparticles based on MIL-101 metal-organic...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Nanoparticles based on MIL-101 metal-organic...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Nanoparticles based on MIL-101 metal-organic...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticles based on MIL-101 metal-organic...