Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials.
Hyaluronic acid
Systematic review
Tooth extraction
Wound healing
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
08
05
2023
accepted:
16
08
2023
pubmed:
15
11
2023
medline:
15
11
2023
entrez:
14
11
2023
Statut:
ppublish
Résumé
To assess whether in animals or patients with ≥ 1 tooth extracted, hyaluronic acid (HyA) application results in superior healing and/or improved complication management compared to any other treatment or no treatment. Three databases were searched until April 2022. The most relevant eligibility criteria were (1) local application of HyA as adjunct to tooth extraction or as treatment of alveolar osteitis, and (2) reporting of clinical, radiographic, histological, or patient-reported data. New bone formation and/or quality were considered main outcome parameters in preclinical studies, while pain, swelling, and trismus were defined as main outcome parameters in clinical studies. Five preclinical and 22 clinical studies (1062 patients at final evaluation) were included. In preclinical trials, HyA was applied into the extraction socket. Although a positive effect of HyA was seen in all individual studies on bone formation, this effect was not confirmed by meta-analysis. In clinical studies, HyA was applied into the extraction socket or used as spray or mouthwash. HyA application after non-surgical extraction of normally erupted teeth may have a positive effect on soft tissue healing. Based on meta-analyses, HyA application after surgical removal of lower third molars (LM3) resulted in significant reduction in pain perception 7 days postoperatively compared to either no additional wound manipulation or the application of a placebo/carrier. Early post-operative pain, trismus, and extent of swelling were unaffected. HyA application may have a positive effect in pain reduction after LM3 removal, but not after extraction of normally erupted teeth. HyA application may have a positive effect in pain reduction after surgical LM3 removal, but it does not seem to have any impact on other complications or after extraction of normally erupted teeth. Furthermore, it seems not to reduce post-extraction alveolar ridge modeling, even though preclinical studies show enhanced bone formation.
Identifiants
pubmed: 37963982
doi: 10.1007/s00784-023-05227-4
pii: 10.1007/s00784-023-05227-4
pmc: PMC10713798
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7209-7229Informations de copyright
© 2023. The Author(s).
Références
J Clin Periodontol. 2003 Sep;30(9):809-18
pubmed: 12956657
J Clin Periodontol. 2015 Mar;42(3):236-46
pubmed: 25640222
Int J Environ Res Public Health. 2022 Mar 11;19(6):
pubmed: 35328990
Int J Oral Maxillofac Surg. 2002 Jun;31(3):309-17
pubmed: 12190139
J Biol Regul Homeost Agents. 2008 Apr-Jun;22(2):109-16
pubmed: 18597703
J Clin Periodontol. 2002 Nov;29(11):1004-11
pubmed: 12472993
J Clin Periodontol. 2021 Apr;48(4):570-580
pubmed: 33513277
J Evid Based Med. 2016 May;9(2):98-104
pubmed: 26997212
J Periodontol. 2001 Dec;72(12):1647-51
pubmed: 11811499
Life Sci. 2010 Aug 14;87(7-8):215-22
pubmed: 20600151
Arch Oral Biol. 2008 Dec;53(12):1155-62
pubmed: 18692778
J Clin Periodontol. 2022 Mar;49(3):280-291
pubmed: 34961942
J Oral Maxillofac Surg. 2018 May;76(5):926-932
pubmed: 29304325
Maxillofac Plast Reconstr Surg. 2020 Dec 9;42(1):40
pubmed: 33300107
J Pharm Sci. 2018 Feb;107(2):654-661
pubmed: 28987501
J Biol Regul Homeost Agents. 2019 Nov-Dec;33(6):1913-1919
pubmed: 31854180
Clin Oral Investig. 2016 Sep;20(7):1607-16
pubmed: 26556578
Clin Oral Implants Res. 2017 Aug;28(8):982-1004
pubmed: 27458031
J Periodontol. 2016 Jul;87(7):790-5
pubmed: 26991484
Int J Dent. 2014;2014:796102
pubmed: 24987419
J Biol Chem. 2002 Feb 15;277(7):4589-92
pubmed: 11717317
J Oral Maxillofac Surg. 2020 Dec;78(12):2154.e1-2154.e12
pubmed: 32771444
Med Oral Patol Oral Cir Bucal. 2017 Nov 1;22(6):e750-e758
pubmed: 29053647
Braz Oral Res. 2018;32:e84
pubmed: 30231173
Med Oral Patol Oral Cir Bucal. 2015 Sep 01;20(5):e633-9
pubmed: 26116842
Kathmandu Univ Med J (KUMJ). 2010 Jan-Mar;8(29):18-24
pubmed: 21209502
Syst Rev. 2021 Mar 29;10(1):89
pubmed: 33781348
J Periodontol. 2022 Jul;93(7):1072-1082
pubmed: 34773704
J Craniomaxillofac Surg. 2019 Feb;47(2):280-286
pubmed: 30579747
J Craniomaxillofac Surg. 2015 Sep;43(7):1033-7
pubmed: 26027861
BMJ. 2016 Oct 12;355:i4919
pubmed: 27733354
Quintessence Int. 2021;52(4):308-316
pubmed: 33533237
Qual Life Res. 2018 Oct;27(10):2477-2489
pubmed: 29797177
J Periodontol. 2019 Apr;90(4):416-424
pubmed: 30421791
J Biomed Mater Res A. 2011 Mar 1;96(3):575-83
pubmed: 21254389
Front Vet Sci. 2019 Jun 25;6:192
pubmed: 31294035
Clin Oral Investig. 2021 Feb;25(2):617-625
pubmed: 32833133
Niger J Clin Pract. 2017 Dec;20(12):1626-1631
pubmed: 29378998
J R Stat Soc Ser A Stat Soc. 2009 Jan;172(1):137-159
pubmed: 19381330
Int J Environ Res Public Health. 2019 Oct 01;16(19):
pubmed: 31581430
Int J Oral Maxillofac Implants. 2018 Mar 15;33(3):636–644
pubmed: 29543928
J Mater Sci Mater Med. 2004 Apr;15(4):311-4
pubmed: 15332591
BMJ. 2019 Aug 28;366:l4898
pubmed: 31462531
J Periodontol. 2021 Nov;92(11):1646-1658
pubmed: 33258112
Clin Oral Implants Res. 2012 Aug;23(8):938-42
pubmed: 21689163
Int J Oral Maxillofac Surg. 2014 Nov;43(11):1399-403
pubmed: 24924267
Quintessence Int. 2018;49(10):831-840
pubmed: 30264056
J Appl Oral Sci. 2017 Mar-Apr;25(2):211-216
pubmed: 28403362
Oral Dis. 2013 Jul;19(5):484-93
pubmed: 23107153
Carbohydr Polym. 2022 Jan 15;276:118699
pubmed: 34823813
BMC Med Res Methodol. 2014 Mar 26;14:43
pubmed: 24667063
J Periodontol. 2021 Nov;92(11):1564-1575
pubmed: 33484160
Biomolecules. 2021 Aug 04;11(8):
pubmed: 34439823
Vojnosanit Pregl. 2016 Nov;73(11):1010-5
pubmed: 29328639
J Bone Jt Infect. 2017 Jan 1;2(1):63-72
pubmed: 28529865
Med Oral Patol Oral Cir Bucal. 2020 Mar 1;25(2):e233-e239
pubmed: 32062667
J Appl Oral Sci. 2018;26:e20170245
pubmed: 29742264
Clin Oral Implants Res. 2017 Jul;28(7):871-876
pubmed: 27252126
Med Oral Patol Oral Cir Bucal. 2020 Mar 1;25(2):e154-e160
pubmed: 32040462