Seasonal variations in endothelium-dependent flow-mediated vasodilation and endothelium-independent nitroglycerine-induced vasodilation.

Endothelial function Endothelium-independent vasodilation Flow-mediated vasodilation Nitroglycerine-induced vasodilation Season

Journal

Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690

Informations de publication

Date de publication:
15 Nov 2023
Historique:
received: 01 08 2023
accepted: 13 10 2023
revised: 12 10 2023
medline: 15 11 2023
pubmed: 15 11 2023
entrez: 14 11 2023
Statut: aheadofprint

Résumé

Cardiovascular mortality has been shown to vary seasonally. However, it has not been determined whether vascular function is affected by the season. The purpose of this study was to investigate the associations of vascular function with season and outdoor temperature. Between April 2007 and March 2022, measurements of flow-mediated vasodilation (FMD) of the brachial artery as an index of endothelial function and nitroglycerine-induced vasodilation (NID) as an index of endothelium-independent vasodilation were performed in 2190 subjects. There was no significant seasonal difference in FMD (spring, 3.9 ± 3.1%; summer, 3.5 ± 3.0%; fall, 3.7 ± 3.0%; winter, 3.6 ± 3.2%; P = 0.14). There was no significant correlation between FMD and daily mean outdoor temperature (r = -0.02, P = 0.25). Multivariate analyses revealed that neither season (β = -0.020, P = 0.31) nor outdoor temperature (β = 0.005, P = 0.81) was significantly associated with FMD after adjustment for other confounding factors. There were significant seasonal differences in NID (spring, 12.8 ± 6.3%; summer, 12.0 ± 6.1%; fall, 11.7 ± 6.1%; winter, 12.3 ± 5.9%; P = 0.02). However, multivariate analysis revealed that there was no significant association between season and NID after adjustment for other confounding factors (β = -0.012, P = 0.56). There was no significant correlation between NID and daily outdoor mean temperature (r = -0.03, P = 0.17). Multivariate analysis revealed that outdoor temperature was not significantly associated with NID (β = -0.006, P = 0.78). There was no significant association of FMD or NID with season or outdoor temperature, suggesting that it is not necessary to take into account the effects of season and outdoor temperature on vascular function when interpreting the results of FMD and NID measurements. Public trials registry number: UMIN000039512.

Identifiants

DOI: 10.1038/s41440-023-01504-7 PMID: 37964068
pubmed: 37964068
doi: 10.1038/s41440-023-01504-7
pii: 10.1038/s41440-023-01504-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to The Japanese Society of Hypertension.

Références

Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, et al. The assessment of endothelial function: from research into clinical practice. Circulation. 2012;126:753–67.
doi: 10.1161/CIRCULATIONAHA.112.093245 pubmed: 22869857 pmcid: 3427943
Maruhashi T, Kihara Y, Higashi Y. Assessment of endothelium-independent vasodilation: from methodology to clinical perspectives. J Hypertens. 2018;36:1460–7.
doi: 10.1097/HJH.0000000000001750 pubmed: 29664811
Adams MR, Robinson J, McCredie R, Seale JP, Sorensen KE, Deanfield JE, et al. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J Am Coll Cardiol. 1998;32:123–7.
doi: 10.1016/S0735-1097(98)00206-X pubmed: 9669259
Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation. 2005;111:363–8.
doi: 10.1161/01.CIR.0000153339.27064.14 pubmed: 15668353
Matsuzawa Y, Kwon TG, Lennon RJ, Lerman LO, Lerman A. Prognostic value of flow-mediated vasodilation in brachial artery and fingertip artery for cardiovascular events: a systematic review and meta-analysis. J Am Heart Assoc. 2015;4:e002270.
doi: 10.1161/JAHA.115.002270 pubmed: 26567372 pmcid: 4845238
Kajikawa M, Maruhashi T, Hida E, Iwamoto Y, Matsumoto T, Iwamoto A, et al. Combination of flow-mediated vasodilation and nitroglycerine-induced vasodilation is more effective for prediction of cardiovascular events. Hypertension. 2016;67:1045–52.
doi: 10.1161/HYPERTENSIONAHA.115.06839 pubmed: 26975705
Akamatsu D, Sato A, Goto H, Watanabe T, Hashimoto M, Shimizu T, et al. Nitroglycerin-mediated vasodilatation of the brachial artery may predict long-term cardiovascular events irrespective of the presence of atherosclerotic disease. J Atheroscler Thromb. 2010;17:1266–74.
doi: 10.5551/jat.5181 pubmed: 20972354
Bhatnagar A. Environmental determinants of cardiovascular disease. Circ Res. 2017;121:162–80.
doi: 10.1161/CIRCRESAHA.117.306458 pubmed: 28684622 pmcid: 5777598
Tanaka H, Shinjo M, Tsukuma H, Kawazuma Y, Shimoji S, Kinoshita N, et al. Seasonal variation in mortality from ischemic heart disease and cerebrovascular disease in Okinawa and Osaka: the possible role of air temperature. J Epidemiol. 2000;10:392–8.
doi: 10.2188/jea.10.392 pubmed: 11210108
Barnett AG, de Looper M, Fraser JF. The seasonality in heart failure deaths and total cardiovascular deaths. Aust N Z J Public Health. 2008;32:408–13.
doi: 10.1111/j.1753-6405.2008.00270.x pubmed: 18959541
Widlansky ME, Vita JA, Keyes MJ, Larson MG, Hamburg NM, Levy D, et al. Relation of season and temperature to endothelium-dependent flow-mediated vasodilation in subjects without clinical evidence of cardiovascular disease (from the Framingham Heart Study). Am J Cardiol. 2007;100:518–23.
doi: 10.1016/j.amjcard.2007.03.055 pubmed: 17659939 pmcid: 1994775
Iwata M, Miyashita Y, Kumagai H. Seasonal variation of endothelium-dependent flow-mediated vasodilation measured in the same subjects. Am J Cardiovasc Dis. 2012;2:111–5.
pubmed: 22720200 pmcid: 3371618
Honda H, Igaki M, Komatsu M, Tanaka SI. Seasonal variations on endothelium-dependent flow-mediated vasodilation in adults with type 2 diabetes and nondiabetic adults with hypertension and/or dyslipidaemia who perform regular exercise. Endocrinol Diabetes Metabol. 2021;4:e00168.
doi: 10.1002/edm2.168
Nawrot TS, Staessen JA, Fagard RH, Van Bortel LM, Struijker-Boudier HA. Endothelial function and outdoor temperature. Eur J Epidemiol. 2005;20:407–10.
doi: 10.1007/s10654-005-1068-x pubmed: 16080588
Klein-Weigel P, Krall K, Falkensammer J, Heinz-Erian P, Ulmer H, Fraedrich G. Lack of seasonal variation in flow-mediated dilatation of the brachial artery in women with primary Raynaud’s phenomenon and healthy controls. Vasa. 2003;32:69–73.
doi: 10.1024/0301-1526.32.2.69 pubmed: 12945098
Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Hypertens Res. 2019;42:1235–481.
doi: 10.1038/s41440-019-0284-9 pubmed: 31375757
American Diabetes Association: clinical practice recommendations 1999. Diabetes Care. 1999;22S1–114.
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama. 2001;285:2486-97.
Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982–92.
doi: 10.1053/j.ajkd.2008.12.034 pubmed: 19339088
Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Disease 2022. https://www.j-athero.org/jp/wp-content/uploads/publications/pdf/GL2022_s/jas_gl2022_3_230210.pdf
Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257–65.
doi: 10.1016/S0735-1097(01)01746-6 pubmed: 11788217
Inoue T, Matsuoka H, Higashi Y, Ueda S, Sata M, Shimada KE, et al. Flow-mediated vasodilation as a diagnostic modality for vascular failure. Hypertens Res. 2008;31:2105–13.
doi: 10.1291/hypres.31.2105 pubmed: 19139600
Thijssen DHJ, Bruno RM, van Mil A, Holder SM, Faita F, Greyling A, et al. Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur Heart J. 2019;40:2534–47.
doi: 10.1093/eurheartj/ehz350 pubmed: 31211361

Auteurs

Tatsuya Maruhashi (T)

Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Masato Kajikawa (M)

Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Shinji Kishimoto (S)

Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Takayuki Yamaji (T)

Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Takahiro Harada (T)

Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Yu Hashimoto (Y)

Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Aya Mizobuchi (A)

Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Shunsuke Tanigawa (S)

Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Farina Mohamad Yusoff (FM)

Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Yukiko Nakano (Y)

Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Kazuaki Chayama (K)

Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Ayumu Nakashima (A)

Department of Stem Cell Biology and Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

Chikara Goto (C)

Department of Rehabilitation, Faculty of general Rehabilitation, Hiroshima International University, 555-36, Kurosegakuendai, Higashihiroshima, Japan.

Yukihito Higashi (Y)

Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. yhigashi@hiroshima-u.ac.jp.
Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. yhigashi@hiroshima-u.ac.jp.

Classifications MeSH