Effects of vincristine and monosodium glutamate on gastrointestinal motility and visceral sensitivity.
gastric emptying
intestinal transit
monosodium glutamate
peripheral neuropathy
vincristine
visceral pain
Journal
Neurogastroenterology and motility
ISSN: 1365-2982
Titre abrégé: Neurogastroenterol Motil
Pays: England
ID NLM: 9432572
Informations de publication
Date de publication:
14 Nov 2023
14 Nov 2023
Historique:
revised:
05
10
2023
received:
01
05
2023
accepted:
17
10
2023
medline:
15
11
2023
pubmed:
15
11
2023
entrez:
14
11
2023
Statut:
aheadofprint
Résumé
Chemotherapy-induced adverse effects are an unresolved nightmare. In preclinical studies in rats, the food additive monosodium glutamate (MSG) improved some of the side effects caused by cisplatin, but its effects in other models of chemotherapy-treated animals are not well known. The aim of this study was to test if MSG may improve some of the adverse effects induced by vincristine in rats. Young male Wistar rats were exposed or not to MSG (4 g L Vincristine reduced body weight gain, food intake, and upper gastrointestinal transit, caused somatic (but not visceral) hypersensitivity and increased the thickness of the submucosal and muscle layers of the small intestine. In vincristine-treated animals, MSG partially prevented gastrointestinal dysmotility and reduced visceral sensitivity but did not improve structural alterations of the small intestine. MSG could be used as an adjuvant to conventional treatments to improve some gastrointestinal dysfunctions caused by chemotherapy.
Sections du résumé
BACKGROUND
BACKGROUND
Chemotherapy-induced adverse effects are an unresolved nightmare. In preclinical studies in rats, the food additive monosodium glutamate (MSG) improved some of the side effects caused by cisplatin, but its effects in other models of chemotherapy-treated animals are not well known. The aim of this study was to test if MSG may improve some of the adverse effects induced by vincristine in rats.
METHODS
METHODS
Young male Wistar rats were exposed or not to MSG (4 g L
KEY RESULTS
RESULTS
Vincristine reduced body weight gain, food intake, and upper gastrointestinal transit, caused somatic (but not visceral) hypersensitivity and increased the thickness of the submucosal and muscle layers of the small intestine. In vincristine-treated animals, MSG partially prevented gastrointestinal dysmotility and reduced visceral sensitivity but did not improve structural alterations of the small intestine.
CONCLUSIONS & INFERENCES
CONCLUSIONS
MSG could be used as an adjuvant to conventional treatments to improve some gastrointestinal dysfunctions caused by chemotherapy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14704Subventions
Organisme : Asociación Española de Gastroenterología y Motilidad
Organisme : Comunidad de Madrid
Organisme : Fundación Mapfre
Organisme : Grupo Español de Motilidad Digestiva
Organisme : Ministerio de Ciencia e Innovación
Organisme : Ministerio de Ciencia, Innovación y Universidades
Organisme : Universidad Rey Juan Carlos
Informations de copyright
© 2023 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.
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