Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.
Cancer
Clinical genetics
Oncology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
received:
10
02
2023
revised:
01
08
2023
accepted:
06
10
2023
medline:
15
11
2023
pubmed:
15
11
2023
entrez:
15
11
2023
Statut:
epublish
Résumé
Gastroesophageal adenocarcinoma (GEA) is an aggressive malignancy with chromosomal instability (CIN). To understand adaptive responses enabling DNA damage response (DDR) and CIN, we analyzed matched normal, premalignant, and malignant gastric lesions from human specimens and a carcinogen-induced mouse model, observing activation of replication stress, DDR, and p21 in neoplastic progression. In GEA cell lines, expression of DDR markers correlated with ploidy abnormalities, such as number of high-level focal amplifications and whole-genome duplication (WGD). Integrating
Identifiants
pubmed: 37965133
doi: 10.1016/j.isci.2023.108169
pii: S2589-0042(23)02246-0
pmc: PMC10641495
doi:
Types de publication
Journal Article
Langues
eng
Pagination
108169Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK120930
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
H.S. receives research funding from AstraZeneca, consulting fees from Dewpoint therapeutics, Merck Sharp and Dohme. J.M.C. receives research funding to his institution from Merus, Roche, Servier, and Bristol Myers Squibb. J.M.C receives research support from Merck, AstraZeneca, Esperas Pharma, Bayer, Tesaro, Arcus Biosciences, and Apexigen; he has also received honoraria for being on the advisory boards of Incyte and Blueprint Medicines and has given educational talks sponsored by Bayer, Merck, AstraZeneca, and Genentech. N.S.S. is on the scientific advisory board for and received compensation from Astrin Biosciences.
Références
Nature. 2021 May;593(7860):E15
pubmed: 33976417
World J Gastrointest Oncol. 2016 Sep 15;8(9):673-81
pubmed: 27672425
Cancer Cell. 2018 Apr 9;33(4):721-735.e8
pubmed: 29622466
J Thorac Oncol. 2019 Dec;14(12):2152-2163
pubmed: 31470128
Mol Cancer Ther. 2018 Aug;17(8):1670-1682
pubmed: 29891488
Nat Genet. 2015 Sep;47(9):1047-55
pubmed: 26192918
Dev Cell. 2018 Feb 26;44(4):420-431
pubmed: 29486194
Nucleic Acids Res. 2016 May 5;44(8):e71
pubmed: 26704973
Neoplasia. 2017 May;19(5):412-420
pubmed: 28431273
Cold Spring Harb Perspect Med. 2016 Mar 01;6(3):a026104
pubmed: 26931810
Nucleic Acids Res. 2012 Sep 1;40(17):8440-8
pubmed: 22753029
Clin Cancer Res. 2017 Aug 1;23(15):4441-4449
pubmed: 28747339
Nature. 2019 May;569(7757):503-508
pubmed: 31068700
Cancer Cell. 2020 Nov 9;38(5):626-628
pubmed: 33171128
Nature. 2012 Mar 28;483(7391):603-7
pubmed: 22460905
Gastroenterology. 2018 Jul;155(1):156-167
pubmed: 29608884
Cancer Chemother Pharmacol. 2020 Jan;85(1):9-20
pubmed: 31512029
Cancer Discov. 2014 Feb;4(2):175-185
pubmed: 24436049
Cytoskeleton (Hoboken). 2011 Feb;68(2):69-88
pubmed: 21246752
Nature. 2021 Feb;590(7846):492-497
pubmed: 33505027
Acta Pathol Microbiol Scand. 1965;64:31-49
pubmed: 14320675
Oncogene. 2013 Jan 31;32(5):577-88
pubmed: 22430210
Radiat Res. 2014 Jan;181(1):1-8
pubmed: 24320053
Nature. 2005 Apr 14;434(7035):864-70
pubmed: 15829956
Lancet Oncol. 2020 Jul;21(7):957-968
pubmed: 32553118
Nat Genet. 2014 Aug;46(8):837-843
pubmed: 24952744
Nature. 2014 Sep 11;513(7517):202-9
pubmed: 25079317
Nat Genet. 2020 Feb;52(2):219-230
pubmed: 32025000
Nature. 2021 Feb;590(7846):486-491
pubmed: 33505028
Nat Cancer. 2020 Feb;1(2):235-248
pubmed: 32613204
Comput Struct Biotechnol J. 2015 Sep 25;13:504-13
pubmed: 26949479
Nucleic Acids Res. 2022 Jul 5;50(W1):W739-W743
pubmed: 35580060
Gut. 2020 Oct;69(10):1738-1749
pubmed: 31937549
Biomed Chromatogr. 2010 Jan;24(1):104-23
pubmed: 19852077
PLoS One. 2014 Apr 16;9(4):e95371
pubmed: 24740294
Clin Cancer Res. 2023 Jan 17;29(2):331-340
pubmed: 36378548
Nat Genet. 2006 Sep;38(9):1043-8
pubmed: 16921376
Sci Transl Med. 2014 Mar 26;6(229):229ra42
pubmed: 24670686
Nat Commun. 2015 Jul 06;6:7668
pubmed: 26144554
Cancers (Basel). 2021 Nov 24;13(23):
pubmed: 34885025
J Cell Biol. 2011 Aug 22;194(4):567-79
pubmed: 21859861
Leukemia. 2010 Apr;24(4):679-86
pubmed: 20130602
Oncotarget. 2016 Jul 5;7(27):42252-60
pubmed: 27323394
Annu Rev Pathol. 2015;10:425-48
pubmed: 25621662
Cell Div. 2015 May 20;10:3
pubmed: 26015801
Cancer Res. 2006 Dec 15;66(24):11594-9
pubmed: 17178852