Histological and histomorphometric analysis of bone tissue using customized titanium meshes with or without resorbable membranes: A randomized clinical trial.
biopsies
bone regeneration
cad cam
histomorphometry
randomized clinical trial
resorbable membrane
titanium mesh
Journal
Clinical oral implants research
ISSN: 1600-0501
Titre abrégé: Clin Oral Implants Res
Pays: Denmark
ID NLM: 9105713
Informations de publication
Date de publication:
15 Nov 2023
15 Nov 2023
Historique:
revised:
29
10
2023
received:
28
03
2023
accepted:
01
11
2023
pubmed:
15
11
2023
medline:
15
11
2023
entrez:
15
11
2023
Statut:
aheadofprint
Résumé
To date, no clinical studies have investigated the effect of using resorbable collagen membrane in conjunction with customized titanium mesh to promote bone formation in guided bone regeneration. Therefore, a non-inferiority analysis (one-sided 95% CI approach) was designed to compare the augmented bone gained using meshes with and without collagen membranes, through histological and histomorphometric investigations. Thirty patients undergoing bone augmentation procedures at both maxillary and mandible sites were randomly treated with customized titanium meshes alone (M-, n = 15) or covered with resorbable membrane (M+, n = 15), in both cases filled with autogenous bone and xenograft. After 6 months of healing, bone tissue biopsies were taken from the augmented region. The bone tissue (B.Ar), grafting material (G.Ar), and non-mineralized tissue (NMT.Ar) areas were quantified through histomorphometric analysis, as were the osteoid area (O.Ar) and its width. Collagen membrane did not appear to significantly influence the investigated parameters: B.Ar, G.Ar, NMT.Ar, and O.Ar were similar between Group M- (34.3%, 11.5%, 54.1%, 1.95 μm The application of collagen membrane over titanium mesh did not lead to significant results. Bone formation appeared significantly different in the maxilla compared with the mandible. Additional studies are required to further investigate the issues observed.
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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