Efficacy οf Wet Age-related Macular Degeneration Treatment οn Reading: A Pilot Study Using Eye-movement Analysis.
Journal
Optometry and vision science : official publication of the American Academy of Optometry
ISSN: 1538-9235
Titre abrégé: Optom Vis Sci
Pays: United States
ID NLM: 8904931
Informations de publication
Date de publication:
01 Oct 2023
01 Oct 2023
Historique:
medline:
16
11
2023
pubmed:
15
11
2023
entrez:
15
11
2023
Statut:
ppublish
Résumé
Functional vision, as evaluated with silent passage reading speed, improves after anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with wet age-related macular antidegeneration (wAMD), reflecting primarily a concomitant reduction in the number of fixations. Implementing eye movement analysis when reading may better characterize the effectiveness of therapeutic approaches in wAMD. This study aimed to evaluate silent reading performance by means of eye fixation analysis before and after anti-VEGF treatment in wAMD patients. Sixteen wAMD patients who underwent anti-VEGF treatment in one eye and visual acuity (VA) better than 0.5 logMAR served as the AMD group. Twenty adults without ocular pathology served as the control group. Central retinal thickness and near VA were assessed at baseline and 3 to 4 months after their first visit. Reading performance was evaluated using short passages of 0.4-logMAR print size. Eye movements were recorded using EyeLink II video eye tracker. Data analysis included computation of reading speed, fixation duration, number of fixations, and percentage of regressions. Frequency distributions of fixation durations were analyzed with ex-Gaussian fittings. In the AMD group, silent reading speed in the treated eye correlated well with central retinal thickness reduction and improved significantly by an average of 15.9 ± 28.5 words per minute (P = .04). This improvement was accompanied by an average reduction of 0.24 ± 0.38 in fixations per word (P = .03). The corresponding improvement in monocular VA was not statistically significant. Other eye fixation parameters did not change significantly after treatment. No statistically significant differences were found in the control group. Visual acuity tests may underestimate the potential therapeutic effects after anti-VEGF treatment in patients with relatively good acuity who are being treated for wAMD. Evaluating silent reading performance and eye fixation parameters may better characterize the effectiveness of therapeutic approaches in wAMD patients.
Identifiants
pubmed: 37966366
doi: 10.1097/OPX.0000000000002064
pii: 00006324-202310000-00002
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
670-678Informations de copyright
Copyright © 2023 American Academy of Optometry.
Déclaration de conflit d'intérêts
Conflict of Interest Disclosure: SP and EK report financial support from Novartis AG during the conduct of the study. MKT reports financial support from Novartis Hellas. The sponsor provided financial support but had no role in the study design, conduct, analysis and interpretation, or writing of the report.
Références
Wong WL, Su X, Li X, et al. Global Prevalence of Age-related Macular Degeneration and Disease Burden Projection for 2020 and 2040: A Systematic Review and Meta-analysis. Lancet Glob Heal 2014;2:e106–16.
Meyniel C, Bodaghi B, Robert PY. Revisiting Vision Rehabilitation. Front Syst Neurosci 2017;11:82.
Rofagha S, Bhisitkul RB, Boyer DS, et al. Seven-year Outcomes in Ranibizumab-treated Patients in ANCHOR, MARINA, and HORIZON: A Multicenter Cohort Study (SEVEN-UP). Ophthalmology 2013;120:2292–9.
Martin DF, Maguire MG, Ying GS, et al. Ranibizumab and Bevacizumab for Neovascular Age-related Macular Degeneration. N Engl J Med 2011;364:1897–908.
Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for Neovascular Age-related Macular Degeneration. N Engl J Med 2006;355:1419–31.
Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus Verteporfin for Neovascular Age-related Macular Degeneration. N Engl J Med 2006;355:1432–44.
Csaky K, Ferris F, Chew EY, et al. Report from the NEI/FDA Endpoints Workshop on Age-related Macular Degeneration and Inherited Retinal Diseases. Invest Ophthalmol Vis Sci 2017;58:3456–63.
Lesmes LA, Jackson ML, Bex P. Visual Function Endpoints to Enable Dry AMD Clinical Trials. Drug Discov Today Ther Strateg 2013;10:e43–50.
Künzel SH, Lindner M, Sassen J, et al. Association of Reading Performance in Geographic Atrophy Secondary to Age-related Macular Degeneration with Visual Function and Structural Biomarkers. JAMA Ophthalmol 2021;139:1191–9.
Dunbar HM, Behning C, Abdirahman A, et al. Repeatability and Discriminatory Power of Chart-based Visual Function Tests in Individuals with Age-related Macular Degeneration: A Macustar Study Report. JAMA Ophthalmol 2022;140:780–9.
Schneck ME, Lott LA, Haegerstrom-Portnoy G, et al. Visual Function in Eyes with Intermediate AMD with and without Retinal Pigment Abnormalities. Optom Vis Sci 2021;98:64–72.
Nasralah Z, Robinson W, Jackson GR, et al. Measuring Visual Function in Diabetic Retinopathy: Progress in Basic and Clinical Research. J Clin Exp Ophthalmol 2013;04:4–11.
Rubin GS. Measuring Reading Performance. Vision Res 2013;90:43–51.
Mangione CM. Psychometric Properties of the National Eye Institute Visual Function Questionnaire (NEI-VFQ). Arch Ophthalmol 1998;116:1496.
Brown B. Reading Performance in Low Vision Patients: Relation to Contrast and Contrast Sensitivity. Am J Optom Physiol Opt 1981;58:218–26.
Brussee T, van Nispen RM, Klerkx EM, et al. Comparison of Reading Performance Tests Concerning Difficulty of Sentences and Paragraphs and Their Reliability. Ophthalmic Physiol Opt 2015;35:324–35.
Legge GE, Ross JA, Luebker A, et al. Psychophysics of Reading. VIII. The Minnesota Low-vision Reading Test. Optom Vis Sci 1989;66:843–53.
Radner W, Obermayer W, Richter-Mueksch S, et al. The Validity and Reliability of Short German Sentences for Measuring Reading Speed. Graefes Arch Clin Exp Ophthalmol 2002;240:461–7.
Ramulu PY, Swenor BK, Jefferys JL, et al. Description and Validation of a Test to Evaluate Sustained Silent Reading. Invest Ophthalmol Vis Sci 2013;54:673–80.
Lovie-Kitchin JE, Bowers AR, Woods RL. Oral and Silent Reading Performance with Macular Degeneration. Ophthalmic Physiol Opt 2000;20:360–70.
Brussee T, Alagahgi B, van Nispen RM, et al. Measurement Properties of Reading Tests in Subjects with Maculopathy. Acta Ophthalmol 2021;99:275–87.
Chung ST. Reading in the Presence of Macular Disease: A Mini-review. Ophthalmic Physiol Opt 2020;40:171–86.
Kortuem C, Marx T, Altpeter EK, et al. Comparing Reading Speeds for Reading Standardized Single Sentences and Paragraphs in Patients with Maculopathy. Ophthalmic Res 2021;64:512–22.
Legge GE, Pelli DG, Rubin GS, et al. Psychophysics of Reading—II. Low Vision. Vis Res 1985;25:239–52.
Whittaker SG, Lovie-Kitchin J. Visual Requirements for Reading. Optom Vis Sci 1993;70:54–65.
Rayner K, Bertera JH. Reading without a Fovea. Science 1979;206:468–9.
Nieuwenhuis S, Ridderinkhof KR, de Jong R, et al. Inhibitory Inefficiency and Failures of Intention Activation: Age-related Decline in the Control of Saccadic Eye Movements. Psychol Aging 2000;15:635–47.
Crossland MD, Culham LE, Kabanarou SA, et al. Preferred Retinal Locus Development in Patients with Macular Disease. Ophthalmology 2005;112:1579–85.
Tarita Nistor L, González EG, Brin T, et al. Fixation Stability and Viewing Distance in Patients with AMD. Optom Vis Sci 2017;94:239–45.
Bullimore MA, Bailey IL. Reading and Eye Movements in Age-related Maculopathy. Optom Vis Sci 1995;72:125–38.
Paterson KB, McGowan VA, Jordan TR. Filtered Text Reveals Adult Age Differences in Reading: Evidence from Eye Movements. Psychol Aging 2013;28:352–64.
Trauzettel-Klosinski S, Dietz K. Standardized Assessment of Reading Performance: The New International Reading Speed Texts IReST. Invest Ophthalmol Vis Sci 2012;53:5452–61.
Ashby J, Yang J, Evans KH, et al. Eye Movements and the Perceptual Span in Silent and Oral Reading. Atten Percept Psychophys 2012;74:634–40.
Starr MS, Rayner K. Eye Movements during Reading: Some Current Controversies. Trends Cogn Sci 2001;5:156–63.
Rubin GS, Feely M. The Role of Eye Movements during Reading in Patients with Age-related Macular Degeneration (AMD). Neuro-Ophthalmology 2009;33:120–6.
Simos PG, Sideridis GD, Kasselimis D, et al. Reading Fluency Estimates of Current Intellectual Function: Demographic Factors and Effects of Type of Stimuli. J Int Neuropsychol Soc 2013;19:355–61.
Plainis S, Tzatzala P, Orphanos Y, et al. A Modified ETDRS Visual Acuity Chart for European-wide Use. Optom Vis Sci 2007;84:647–53.
Gleni A, Ktistakis E, Tsilimbaris MK, et al. Assessing Variability in Reading Performance with the New Greek Standardized Reading Speed Texts (IReST). Optom Vis Sci 2019;96:761–7.
White SJ, Staub A. The Distribution of Fixation Durations during Reading: Effects of Stimulus Quality. J Exp Psychol Hum Percept Perform 2012;38:603–17.
Kragler S. The Transition from Oral to Silent Reading. Read Psychol 1995;16:395–408.
Cheong AM, Legge GE, Lawrence MG, et al. Relationship between Visual Span and Reading Performance in Age-related Macular Degeneration. Vision Res 2008;48:577–88.
Legge GE, Ahn SJ, Klitz TS, et al. Psychophysics of Reading—XVI. The Visual Span in Normal and Low Vision. Vision Res 1997;37:1999–2010.
Scherlen AC, Bernard JB, Calabrese A, et al. Page Mode Reading with Simulated Scotomas: Oculo-motor Patterns. Vision Res 2008;48:1870–8.
Calabrèse A, Bernard JB, Faure G, et al. Eye Movements and Reading Speed in Macular Disease: The Shrinking Perceptual Span Hypothesis Requires and Is Supported by a Mediation Analysis. Invest Ophthalmol Vis Sci 2014;55:3638–45.
Crossland MD, Rubin GS. Eye Movements and Reading in Macular Disease: Further Support for the Shrinking Perceptual Span Hypothesis. Vision Res 2006;46:590–7.
Rayner K. The Perceptual Span and Peripheral Cues in Reading. Cogn Psychol 1975;7:65–81.
Ramulu PY, Swenor BK, Jefferys JL, et al. Difficulty with Out-loud and Silent Reading in Glaucoma. Invest Ophthalmol Vis Sci 2013;54:666–72.
Lindner M, Pfau M, Czauderna J, et al. Determinants of Reading Performance in Eyes with Foveal-sparing Geographic Atrophy. Ophthalmol Retina 2019;3:201–10.
Hariri AH, Tepelus TC, Akil H, et al. Retinal Sensitivity at the Junctional Zone of Eyes with Geographic Atrophy Due to Age-related Macular Degeneration. Am J Ophthalmol 2016;168:122–8.
Altinbay D, Idil A, Sahli E. How Much Do Clinical and Microperimetric Findings Affect Reading Speed in Low Vision Patients with Age-related Macular Degeneration? Curr Eye Res 2021;46:1581–8.
Kodjikian L, Creuzot-Garcher C, Korobelnik JF, et al. Microperimetry to Predict Disease Progression in Eyes at High Risk of Age-related Macular Degeneration Disease: The Prevision Study. Acta Ophthalmol 2023;101:E135–42.
Murray IJ, Rodrigo-Diaz E, Kelly JM, et al. The Role of Dark Adaptation in Understanding Early AMD. Prog Retin Eye Res 2022;88:101015.