Hydrogen sulfide attenuates depression-like behaviours in Parkinson's disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner.
Depression-like behaviour
Hippocampal synaptic plasticity
Hydrogen sulfide
Parkinson's disease
Warburg effect
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
13 Nov 2023
13 Nov 2023
Historique:
received:
17
09
2023
revised:
07
11
2023
accepted:
09
11
2023
pubmed:
16
11
2023
medline:
16
11
2023
entrez:
15
11
2023
Statut:
aheadofprint
Résumé
Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H To investigate whether H We utilised rotenone to develop a PD model with subcutaneous injections in the dorsal cervical region of Sprague-Dawley rats. The depression-like behaviours in the rotenone-induced PD model rats were assessed through forced swimming, tail suspension, open field, novelty-suppressed feeding, and elevated plus-maze tests. The expression of postsynaptic density protein-95 and synapsin-1, related to synaptic plasticity, was detected using Western blot in the hippocampus. The hippocampal ultrastructure, including the synaptic density, length of the synaptic active zone, postsynaptic density thickness, and synaptic gap width, was detected using transmission electron microscopy. We proved that sodium hydrosulfide (NaHS; a donor of H H
Sections du résumé
BACKGROUND
BACKGROUND
Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H
OBJECTIVE
OBJECTIVE
To investigate whether H
METHODS
METHODS
We utilised rotenone to develop a PD model with subcutaneous injections in the dorsal cervical region of Sprague-Dawley rats. The depression-like behaviours in the rotenone-induced PD model rats were assessed through forced swimming, tail suspension, open field, novelty-suppressed feeding, and elevated plus-maze tests. The expression of postsynaptic density protein-95 and synapsin-1, related to synaptic plasticity, was detected using Western blot in the hippocampus. The hippocampal ultrastructure, including the synaptic density, length of the synaptic active zone, postsynaptic density thickness, and synaptic gap width, was detected using transmission electron microscopy.
RESULTS
RESULTS
We proved that sodium hydrosulfide (NaHS; a donor of H
CONCLUSION
CONCLUSIONS
H
Identifiants
pubmed: 37967673
pii: S0091-3057(23)00164-8
doi: 10.1016/j.pbb.2023.173677
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173677Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that there is no conflict of interest.