Role reversals: non-canonical roles for immune and non-immune cells in the gut.
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
13 Nov 2023
13 Nov 2023
Historique:
received:
17
08
2023
revised:
07
11
2023
accepted:
07
11
2023
pubmed:
16
11
2023
medline:
16
11
2023
entrez:
15
11
2023
Statut:
aheadofprint
Résumé
The intestine is home to an intertwined network of epithelial, immune, and neuronal cells as well as the microbiome, with implications for immunity, systemic metabolism, and behavior. While the complexity of this microenvironment has long since been acknowledged, recent technological advances have propelled our understanding to an unprecedented level. Notably, the microbiota and non-immune or structural cells have emerged as important conductors of intestinal immunity, and by contrast, cells of both the innate and adaptive immune systems have demonstrated non-canonical roles in tissue repair and metabolism. This review highlights recent works in the following two streams: non-immune cells of the intestine performing immunological functions; and traditional immune cells exhibiting non-immune functions in the gut.
Identifiants
pubmed: 37967720
pii: S1933-0219(23)00087-9
doi: 10.1016/j.mucimm.2023.11.004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.