Steroidal Saponins from Solanum lyratum Thunb.
Solanaceae
Solanum lyratum
cytotoxicity
steroidal alkaloid
steroidal saponin
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
15 Nov 2023
15 Nov 2023
Historique:
received:
07
09
2023
accepted:
13
11
2023
pubmed:
16
11
2023
medline:
16
11
2023
entrez:
15
11
2023
Statut:
aheadofprint
Résumé
Four undescribed steroidal compounds along with twenty known compounds were isolated from n-butanol extracted fraction of the whole plants of Solanum lyratum Thunb (SLNF). Their structures were assigned based on analyses of the extensive spectroscopic data (including MS, 1D/2D NMR, and ECD) or comparisons of the NMR data with those reported. Among the knowns, three compounds were isolated from Solanum plants for the first time, while one compound was isolated from S. lyratum for the first time. In addition, the cytotoxicities of these isolates against human colon SW480 and hepatoma Hep3B cells were evaluated by a MTT assay. And, nine of them and SLNF exhibited significant activities against both SW480 and Hep3B cells, while twelve of them significantly inhibited the activities of SW480 cells. This study allows for the exploitation of chemical markers with potential significance in discrimination of Solanum plants, and uncovers the diverse steroidal constituents from S. lyratum dedicated for its future application in cancer treatment.
Identifiants
pubmed: 37968243
doi: 10.1002/cbdv.202301381
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301381Subventions
Organisme : Tianjin Committee of Science and Technology of China
ID : 22ZYJDSS00040
Organisme : National Key Research and Development Project of China
ID : 2021YFE0203100
Informations de copyright
© 2023 Wiley-VHCA AG, Zurich, Switzerland.
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