The extracellular matrix dictates regional competence for tumour initiation.
Animals
Mice
Cell Transformation, Neoplastic
/ metabolism
Collagen
/ metabolism
Epidermis
/ pathology
Extracellular Matrix
/ metabolism
Skin Neoplasms
/ pathology
Tumor Microenvironment
Carcinoma, Basal Cell
/ pathology
Ear
/ pathology
Collagenases
/ metabolism
Aging
Ultraviolet Rays
Mutant Proteins
/ genetics
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
27
04
2022
accepted:
11
10
2023
medline:
24
11
2023
pubmed:
16
11
2023
entrez:
15
11
2023
Statut:
ppublish
Résumé
The skin epidermis is constantly renewed throughout life
Identifiants
pubmed: 37968399
doi: 10.1038/s41586-023-06740-y
pii: 10.1038/s41586-023-06740-y
doi:
Substances chimiques
Collagen
9007-34-5
Collagenases
EC 3.4.24.-
Smo protein, mouse
0
Mutant Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
828-835Subventions
Organisme : European Research Council
ID : 885093
Pays : International
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
Références
Blanpain, C. & Fuchs, E. Epidermal stem cells of the skin. Annu. Rev. Cell Dev. Biol. 22, 339–373 (2006).
pubmed: 16824012
pmcid: 2405915
doi: 10.1146/annurev.cellbio.22.010305.104357
Hsu, Y. C. & Fuchs, E. Building and maintaining the skin. Cold Spring Harb. Perspect. Biol. 14, a040840 (2022).
pubmed: 34607830
doi: 10.1101/cshperspect.a040840
Blanpain, C. & Simons, B. D. Unravelling stem cell dynamics by lineage tracing. Nat. Rev. Mol. Cell Biol. 14, 489–502 (2013).
pubmed: 23860235
doi: 10.1038/nrm3625
Epstein, E. H. Basal cell carcinomas: attack of the hedgehog. Nat. Rev. Cancer 8, 743–754 (2008).
pubmed: 18813320
pmcid: 4457317
doi: 10.1038/nrc2503
Kasper, M., Jaks, V., Hohl, D. & Toftgard, R. Basal cell carcinoma—molecular biology and potential new therapies. J. Clin. Invest. 122, 455–463 (2012).
pubmed: 22293184
pmcid: 3266783
doi: 10.1172/JCI58779
Youssef, K. K. et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat. Cell Biol. 12, 299–305 (2010).
pubmed: 20154679
doi: 10.1038/ncb2031
Mao, J. et al. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 66, 10171–10178 (2006).
pubmed: 17047082
pmcid: 3806052
doi: 10.1158/0008-5472.CAN-06-0657
Di Gregorio, A., Bowling, S. & Rodriguez, T. A. Cell competition and its role in the regulation of cell fitness from development to cancer. Dev. Cell 38, 621–634 (2016).
pubmed: 27676435
doi: 10.1016/j.devcel.2016.08.012
Merino, M. M., Levayer, R. & Moreno, E. Survival of the fittest: essential roles of cell competition in development, aging, and cancer. Trends Cell Biol. 26, 776–788 (2016).
pubmed: 27319281
doi: 10.1016/j.tcb.2016.05.009
Levayer, R. Solid stress, competition for space and cancer: the opposing roles of mechanical cell competition in tumour initiation and growth. Semin. Cancer Biol. 63, 69–80 (2020).
pubmed: 31077845
pmcid: 7221353
doi: 10.1016/j.semcancer.2019.05.004
Moreno, E. & Basler, K. dMyc transforms cells into super-competitors. Cell 117, 117–129 (2004).
pubmed: 15066287
doi: 10.1016/S0092-8674(04)00262-4
de la Cova, C., Abril, M., Bellosta, P., Gallant, P. & Johnston, L. A. Drosophila Myc regulates organ size by inducing cell competition. Cell 117, 107–116 (2004).
pubmed: 15066286
doi: 10.1016/S0092-8674(04)00214-4
Kakiuchi, N. & Ogawa, S. Clonal expansion in non-cancer tissues. Nat. Rev. Cancer 21, 239–256 (2021).
pubmed: 33627798
doi: 10.1038/s41568-021-00335-3
Sanchez-Danes, A. et al. Defining the clonal dynamics leading to mouse skin tumour initiation. Nature 536, 298–303 (2016).
pubmed: 27459053
pmcid: 5068560
doi: 10.1038/nature19069
Mascre, G. et al. Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature 489, 257–262 (2012).
pubmed: 22940863
doi: 10.1038/nature11393
Clayton, E. et al. A single type of progenitor cell maintains normal epidermis. Nature 446, 185–189 (2007).
pubmed: 17330052
doi: 10.1038/nature05574
Fiore, V. F. et al. Mechanics of a multilayer epithelium instruct tumour architecture and function. Nature 585, 433–439 (2020).
pubmed: 32879493
pmcid: 7787055
doi: 10.1038/s41586-020-2695-9
Levayer, R., Dupont, C. & Moreno, E. Tissue crowding induces caspase-dependent competition for space. Curr. Biol. 26, 670–677 (2016).
pubmed: 26898471
pmcid: 4791483
doi: 10.1016/j.cub.2015.12.072
Tsuboi, A. et al. Competition for space is controlled by apoptosis-induced change of local epithelial topology. Curr. Biol. 28, 2115–2128 (2018).
pubmed: 29910075
doi: 10.1016/j.cub.2018.05.029
Moreno, E., Valon, L., Levillayer, F. & Levayer, R. Competition for space induces cell elimination through compaction-driven ERK downregulation. Curr. Biol. 29, 23–34 (2019).
pubmed: 30554899
pmcid: 6331351
doi: 10.1016/j.cub.2018.11.007
Villeneuve, C. et al. Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture. Preprint at bioRxiv https://doi.org/10.1101/2022.12.12.519937 (2022).
van Neerven, S. M. & Vermeulen, L. Cell competition in development, homeostasis and cancer. Nat. Rev. Mol. Cell Biol. 24, 221–236 (2023).
pubmed: 36175766
doi: 10.1038/s41580-022-00538-y
Sandoval, M., Ying, Z. & Beronja, S. Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium. eLife 10, e54618 (2021).
pubmed: 33393458
pmcid: 7817173
doi: 10.7554/eLife.54618
Aragona, M. et al. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis. Nat. Commun. 8, 14684 (2017).
pubmed: 28248284
pmcid: 5339881
doi: 10.1038/ncomms14684
Dekoninck, S. et al. Defining the design principles of skin epidermis postnatal growth. Cell 181, 604–620 (2020).
pubmed: 32259486
pmcid: 7198979
doi: 10.1016/j.cell.2020.03.015
Joost, S. et al. Single-cell transcriptomics reveals that differentiation and spatial signatures shape epidermal and hair follicle heterogeneity. Cell Syst. 3, 221–237 (2016).
pubmed: 27641957
pmcid: 5052454
doi: 10.1016/j.cels.2016.08.010
Joost, S. et al. Single-cell transcriptomics of traced epidermal and hair follicle stem cells reveals rapid adaptations during wound healing. Cell Rep. 25, 585–597 (2018).
pubmed: 30332640
doi: 10.1016/j.celrep.2018.09.059
Youssef, K. K. et al. Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat. Cell Biol. 14, 1282–1294 (2012).
pubmed: 23178882
doi: 10.1038/ncb2628
Yang, S. H. et al. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat. Genet. 40, 1130–1135 (2008).
pubmed: 19165927
pmcid: 2688690
doi: 10.1038/ng.192
Pieraggi, M. T., Julian, M. & Bouissou, H. Fibroblast changes in cutaneous ageing. Virchows Arch. A Pathol. Anat. Histopathol. 402, 275–287 (1984).
pubmed: 6422618
doi: 10.1007/BF00695081
Salzer, M. C. et al. Identity noise and adipogenic traits characterize dermal fibroblast aging. Cell 175, 1575–1590 (2018).
pubmed: 30415840
doi: 10.1016/j.cell.2018.10.012
Lan, C. E., Hung, Y. T., Fang, A. H. & Ching-Shuang, W. Effects of irradiance on UVA-induced skin aging. J. Dermatol. Sci. 94, 220–228 (2019).
pubmed: 30956032
doi: 10.1016/j.jdermsci.2019.03.005
Wlaschek, M. et al. Solar UV irradiation and dermal photoaging. J. Photochem. Photobiol. B 63, 41–51 (2001).
pubmed: 11684450
doi: 10.1016/S1011-1344(01)00201-9
Kligman, L. H. The hairless mouse model for photoaging. Clin. Dermatol. 14, 183–195 (1996).
pubmed: 9117985
doi: 10.1016/0738-081X(95)00154-8
Martincorena, I. et al. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 348, 880–886 (2015).
pubmed: 25999502
pmcid: 4471149
doi: 10.1126/science.aaa6806
Rognoni, E. et al. Fibroblast state switching orchestrates dermal maturation and wound healing. Mol. Syst. Biol. 14, e8174 (2018).
pubmed: 30158243
pmcid: 6113774
doi: 10.15252/msb.20178174
Rhee, H., Polak, L. & Fuchs, E. Lhx2 maintains stem cell character in hair follicles. Science 312, 1946–1949 (2006).
pubmed: 16809539
pmcid: 2405918
doi: 10.1126/science.1128004
Pineda, C. M. et al. Intravital imaging of hair follicle regeneration in the mouse. Nat. Protoc. 10, 1116–1130 (2015).
pubmed: 26110716
pmcid: 4632978
doi: 10.1038/nprot.2015.070
Aragona, M. et al. Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature 584, 268–273 (2020).
pubmed: 32728211
pmcid: 7116042
doi: 10.1038/s41586-020-2555-7
Maia, T. M. et al. Simple peptide quantification approach for MS-based proteomics quality control. ACS Omega 5, 6754–6762 (2020).
pubmed: 32258910
pmcid: 7114614
doi: 10.1021/acsomega.0c00080
Chiva, C. et al. QCloud: a cloud-based quality control system for mass spectrometry-based proteomics laboratories. PLoS ONE 13, e0189209 (2018).
pubmed: 29324744
pmcid: 5764250
doi: 10.1371/journal.pone.0189209
Mildner, K. et al. Landmark-based retrieval of inflamed skin vessels enabled by 3D correlative intravital light and volume electron microscopy. Histochem. Cell Biol. 158, 127–136 (2022).
pubmed: 35764846
pmcid: 9338004
doi: 10.1007/s00418-022-02119-8