Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis.
Neutrophil
Trichomoniasis
Trichomonosis
Tritrichomonas foetus
Trogocytosis
Journal
Veterinary research communications
ISSN: 1573-7446
Titre abrégé: Vet Res Commun
Pays: Switzerland
ID NLM: 8100520
Informations de publication
Date de publication:
16 Nov 2023
16 Nov 2023
Historique:
received:
26
08
2023
accepted:
08
11
2023
medline:
16
11
2023
pubmed:
16
11
2023
entrez:
15
11
2023
Statut:
aheadofprint
Résumé
The protozoan parasite Tritrichomonas foetus (T. foetus) is the causative organism of bovine trichomonosis (also referred to as trichomoniasis), a sexually-transmitted infection that reduces fertility in cattle. Efforts to control trichomonosis on cattle farms are hindered by the discouragement of antibiotic use in agriculture, and the incomplete, short-lived protection conferred by the current vaccines. A more complete mechanistic understanding of what effective immunity to T. foetus entails could enable the development of more robust infection control strategies. While neutrophils, the primary responders to infection, are present in infected tissues and have been shown to kill the parasite in vitro, the mechanism they use for parasite killing has not been established. Here, we show that primary bovine neutrophils isolated from peripheral blood rapidly kill T. foetus in vitro in a dose-dependent manner, and that optimal parasite killing is reduced by inhibitors of trogocytosis. We also use imaging to show that bovine neutrophils surround T. foetus and trogocytose its membrane. These findings are consistent with killing via trogocytosis, a recently described novel neutrophil antimicrobial mechanism.
Identifiants
pubmed: 37968413
doi: 10.1007/s11259-023-10260-5
pii: 10.1007/s11259-023-10260-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agricultural Research Institute, California State University
ID : 22-04-104, 21-04-112, 23-04-105
Organisme : Agricultural Research Institute, California State University
ID : 22-04-104, 21-04-112, 23-04-105
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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