[Molecular and cellular mechanisms of ageing: modern knowledge (literature review)].
Journal
Problemy endokrinologii
ISSN: 2308-1430
Titre abrégé: Probl Endokrinol (Mosk)
Pays: Russia (Federation)
ID NLM: 0140673
Informations de publication
Date de publication:
11 Nov 2023
11 Nov 2023
Historique:
received:
09
03
2023
accepted:
15
05
2023
revised:
05
05
2023
medline:
17
11
2023
pubmed:
16
11
2023
entrez:
16
11
2023
Statut:
epublish
Résumé
Ageing (as known as eldering, senescence) is a genetically and epigenetically programmed pathophysiological process. Velocity of biological ageing is defined as balance between alteration and reparation of body structures. According to last World Health Organization (WHO) highlights ageing still stays an extremely actual scientific, social and demographic problem: in 2020 total number of people older than 60 years and older was 1 billion people; in 2030 future number may be 1,4 billion people, in 2050 - 2,1 billion people. Absence of single universal theory of aging nowadays is reason for scientifical and clinical collaboration between biologists and doctors, including endocrinologists. Designing of potentially effective newest anti-ageing strategies (such as natural/synthetic telomerase regulators, mesenchymal stem cells etc.) is of interest to scientific community. The aim of present article is a review of modern omics (genomic, proteomic, metabolomic) ageing mechanisms, potential ways of targeted prevention and treatment of age-related disease according to conception of personalized medicine. Present review is narrative, it does not lead to systematic review, meta-analysis and does not aim to commercial advertisement. Review has been provided via PubMed article that have been published since 1979 until 2022.
Identifiants
pubmed: 37968951
doi: 10.14341/probl13278
pmc: PMC10680502
doi:
Types de publication
Review
Meta-Analysis
English Abstract
Journal Article
Langues
rus
Sous-ensembles de citation
IM
Pagination
45-54Références
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