Modular Approach for the Synthesis and Bioactivity Profiling of 8,8'-Biflavones.


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
07 Nov 2023
Historique:
received: 30 08 2023
revised: 20 09 2023
accepted: 25 09 2023
medline: 16 11 2023
pubmed: 16 11 2023
entrez: 16 11 2023
Statut: epublish

Résumé

In this work, we report the scalable and modular synthesis of a library of 55 monomeric and dimeric flavonoids including 14 8,8'-biflavones. The sterically demanding tetra-

Identifiants

pubmed: 37970025
doi: 10.1021/acsomega.3c06503
pmc: PMC10634270
doi:

Types de publication

Journal Article

Langues

eng

Pagination

41816-41834

Informations de copyright

© 2023 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Références

PLoS One. 2014 Mar 24;9(3):e90203
pubmed: 24662942
Molecules. 2022 Mar 09;27(6):
pubmed: 35335145
J Org Chem. 2018 Dec 7;83(23):14362-14384
pubmed: 30376626
Org Lett. 1999 Aug 26;1(4):671-2
pubmed: 10823198
Mini Rev Med Chem. 2017;17(10):834-862
pubmed: 27823559
J Nat Prod. 2016 May 27;79(5):1259-66
pubmed: 27082979
Org Lett. 2011 Sep 2;13(17):4624-7
pubmed: 21827134
Eur J Med Chem. 2014 Oct 30;86:153-64
pubmed: 25151578
Food Chem Toxicol. 2020 Nov;145:111642
pubmed: 32783998
J Am Chem Soc. 2017 Sep 27;139(38):13404-13413
pubmed: 28862442
Antimicrob Agents Chemother. 2006 Apr;50(4):1352-64
pubmed: 16569852
J Org Chem. 2013 Mar 1;78(5):1910-22
pubmed: 23094589
Angew Chem Int Ed Engl. 2003 Feb 24;42(8):931-3
pubmed: 12596181
Acc Chem Res. 2008 Jan;41(1):40-9
pubmed: 18159936
Bioorg Chem. 2010 Aug;38(4):139-43
pubmed: 20457464
Nat Chem. 2015 Mar;7(3):234-40
pubmed: 25698333
Planta Med. 1999 Mar;65(2):120-5
pubmed: 10193201
Curr Top Med Chem. 2015;15(2):105-19
pubmed: 25547095
J Org Chem. 1997 Oct 17;62(21):7222-7227
pubmed: 11671832
J Nat Prod. 2014 Apr 25;77(4):1093-6
pubmed: 24628372
Free Radic Biol Med. 1999 May;26(9-10):1231-7
pubmed: 10381194
Arch Pharm Res. 2008 Mar;31(3):265-73
pubmed: 18409037
Molecules. 2017 Feb 16;22(2):
pubmed: 28212342
J Ethnopharmacol. 2009 Dec 10;126(3):512-7
pubmed: 19761825
Planta Med. 2014 Dec;80(18):1665-71
pubmed: 25338212
J Am Chem Soc. 2019 Jun 26;141(25):10016-10032
pubmed: 31125210
Fortschr Chem Org Naturst. 2001;82:1-249
pubmed: 11892255
Bioorg Med Chem. 2006 Mar 1;14(5):1538-45
pubmed: 16386424
Curr Med Chem. 2015;22(30):3523-32
pubmed: 26179997
Org Biomol Chem. 2021 Nov 3;19(42):9211-9222
pubmed: 34643629
EFSA J. 2019 Dec 11;17(12):e05926
pubmed: 32626211
Bioorg Med Chem Lett. 2003 Oct 20;13(20):3423-7
pubmed: 14505641
Phytochemistry. 2009 Mar;70(5):615-20
pubmed: 19349053
J Org Chem. 2019 Feb 15;84(4):1677-1686
pubmed: 30657316
Chemistry. 2008;14(16):4913-23
pubmed: 18425741
J Am Chem Soc. 2014 May 14;136(19):6782-5
pubmed: 24797179
Bioorg Med Chem. 2007 May 15;15(10):3356-67
pubmed: 17383189
Eur J Med Chem. 2014 Sep 12;84:206-39
pubmed: 25019478
J Nat Prod. 2010 Dec 27;73(12):2064-6
pubmed: 21082806
Mol Cell Endocrinol. 2010 Jul 29;323(2):256-67
pubmed: 20380869
Drug Dev Res. 2018 Feb;79(1):22-28
pubmed: 29130540
Eur J Med Chem. 2014 Apr 22;77:378-87
pubmed: 24675137
J Med Chem. 2016 May 26;59(10):4443-58
pubmed: 26571338
J Am Chem Soc. 2015 Sep 9;137(35):11453-60
pubmed: 26287435
Chem Biodivers. 2007 Nov;4(11):2495-527
pubmed: 18027351
Bioorg Med Chem Lett. 2019 Aug 1;29(15):1994-1997
pubmed: 31138471
Bioorg Med Chem. 2017 Mar 15;25(6):1817-1829
pubmed: 28214231
Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3
pubmed: 26004578
Nat Prod Rep. 2014 Apr;31(4):419-32
pubmed: 24337165
J Am Chem Soc. 2018 May 9;140(18):5969-5975
pubmed: 29658717

Auteurs

Moritz K T Klischan (MKT)

Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, Stetternicher Forst, Geb.15.8, 52426 Jülich, Germany.

Flaminia Mazzone (F)

Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Lena Berning (L)

Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Julian Greb (J)

Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, Stetternicher Forst, Geb.15.8, 52426 Jülich, Germany.

Max Schlamkow (M)

Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, Stetternicher Forst, Geb.15.8, 52426 Jülich, Germany.
Institut für Bio- und Geowissenschaften (IBG-1: Bioorganische Chemie) Forschungszentrum, 52428 Jülich, Germany.

Mona Haase (M)

Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, Stetternicher Forst, Geb.15.8, 52426 Jülich, Germany.

Wolfgang Frey (W)

Institute of Organic Chemistry, University of Stuttgart, 70569 Stuttgart, Germany.

Björn Stork (B)

Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Klaus Pfeffer (K)

Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Jörg Pietruszka (J)

Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, Stetternicher Forst, Geb.15.8, 52426 Jülich, Germany.
Institut für Bio- und Geowissenschaften (IBG-1: Bioorganische Chemie) Forschungszentrum, 52428 Jülich, Germany.

Classifications MeSH