Humoral and cellular factors inhibit phosphate-induced vascular calcification during the growth period.
alkaline phosphatase
chronic kidney disease
fetuin-A
hyperphosphatemia
pyrophosphate
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
07
02
2023
accepted:
25
02
2023
medline:
16
11
2023
pubmed:
16
11
2023
entrez:
16
11
2023
Statut:
ppublish
Résumé
Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether the defence system against Pi-induced vascular calcification can exist during the growth period using mice model. We found that calcification propensity of young serum (aged 3 weeks) was significantly lower than that of adult serum (10 months), possibly due to high fetuin-A levels. In addition, when the aorta was cultured in high Pi medium
Identifiants
pubmed: 37970550
doi: 10.3164/jcbn.23-11
pii: DN/JST.JSTAGE/jcbn/23-11
pmc: PMC10636584
doi:
Types de publication
Journal Article
Langues
eng
Pagination
198-204Informations de copyright
Copyright © 2023 JCBN.
Déclaration de conflit d'intérêts
YK, YO, YA, YM, MS, KO, HO, MM, HYO & YT declare no conflicts of interest.
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