Cumulative detection of anal high-grade squamous intraepithelial lesions over two-year follow-up in men who have sex with men living with HIV in France.
Men who have sex with men
anal cytology
anal high-grade squamous intraepithelial lesions
high resolution anoscopy
human immunodeficiency virus
human papillomavirus
p16/Ki67
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
16 Nov 2023
16 Nov 2023
Historique:
received:
05
06
2023
revised:
02
11
2023
accepted:
13
11
2023
medline:
17
11
2023
pubmed:
17
11
2023
entrez:
16
11
2023
Statut:
aheadofprint
Résumé
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSIL) in men who have sex with men living with HIV who underwent three visits over two years, with cytology and high-resolution anoscopy (HRA), within the ANRS-EP57-APACHES study. Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3.6-18.9), and p16/Ki67 (aOR 4.6; 95%CI 2.3-9.1). Repeat annual cytology and HRA improved HSIL detection but did not fully compensate between-center heterogeneity.
Identifiants
pubmed: 37970975
pii: 7424390
doi: 10.1093/infdis/jiad506
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Cédric Arvieux
(C)
Ana Canestri
(A)
Gary Clifford
(G)
Jean-Damien Combes
(JD)
Valérie Costes-Martineau
(V)
Jean Del Grande
(J)
Jean-Michel Didelot
(JM)
Isabelle Etienney
(I)
Michael Falguières
(M)
Tristan Ferry
(T)
Hugues Fischer
(H)
Jean-Francois Flejou
(JF)
Isabelle Heard
(I)
Sébastien Henno
(S)
Nadia Hoyau
(N)
Marine Landon
(M)
Hélène Laude
(H)
Frédérique Le Breton
(F)
Anne-Carole Lesage
(AC)
Annie Lion
(A)
Gilles Maincent
(G)
Lucie Marchand
(L)
Haingo Njatonirina Andrianiaina
(HN)
Olivier Patey
(O)
Ventzislava Petrov Sanchez
(VP)
Gilles Pialoux
(G)
Marion Pirel
(M)
Lionel Piroth
(L)
Isabelle Poizot-Martin
(I)
Sylvie Radenne
(S)
Emmanuelle Ressiot
(E)
Jacques Reynes
(J)
Laurent Siproudhis
(L)
Catherine Tamalet
(C)
Pierre Tattevin
(P)
Olivia Zaegel-Faucher
(O)
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.