Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential.
Intestinal inflammation
Macrophages
Tissue remodeling
Type 2 cytokines
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
16 Nov 2023
16 Nov 2023
Historique:
revised:
14
11
2023
received:
15
02
2023
accepted:
15
11
2023
pubmed:
17
11
2023
medline:
17
11
2023
entrez:
16
11
2023
Statut:
aheadofprint
Résumé
The initiation of tissue remodeling following damage is a critical step in preventing the development of immune-mediated diseases. Several factors contribute to mucosal healing, leading to innovative therapeutic approaches for managing intestinal disorders. However, uncovering alternative targets and gaining mechanistic insights are imperative to enhance therapy efficacy and broaden its applicability across different intestinal diseases. Here we demonstrate that Nmes1, encoding for Normal Mucosa of Esophagus-Specific gene 1, also known as Aa467197, is a novel regulator of mucosal healing. Nmes1 influences the macrophage response to the tissue remodeling cytokine IL-4 in vitro. In addition, using two murine models of intestinal damage, each characterized by a type 2-dominated environment with contrasting functions, the ablation of Nmes1 results in decreased intestinal regeneration during the recovery phase of colitis, while enhancing parasitic egg clearance and reducing fibrosis during the advanced stages of Schistosoma mansoni infection. These outcomes are associated with alterations in CX3CR1
Identifiants
pubmed: 37971166
doi: 10.1002/eji.202350434
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2350434Subventions
Organisme : Werner Otto Stiftung
Organisme : Landesfoschungsförderung Hamburg
ID : LFF_FV74
Organisme : Pro Exzellenzia Plus
Informations de copyright
© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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