Second edition of the Milan System for Reporting Salivary Gland Cytopathology: Refining the role of salivary gland FNA.
Milan system
carcinoma
fine-needle aspiration
salivary gland
standardised reporting
Journal
Cytopathology : official journal of the British Society for Clinical Cytology
ISSN: 1365-2303
Titre abrégé: Cytopathology
Pays: England
ID NLM: 9010345
Informations de publication
Date de publication:
16 Nov 2023
16 Nov 2023
Historique:
received:
16
10
2023
accepted:
16
10
2023
medline:
17
11
2023
pubmed:
17
11
2023
entrez:
16
11
2023
Statut:
aheadofprint
Résumé
The use of standardised reporting systems for non-gynaecologic cytopathology has made enormous gains in popularity during the past decade, including for thyroid fine-needle aspiration, urine cytology, serous effusions, pancreas, lymph nodes, lung and more. In February 2018, the first edition of the Atlas of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was published. The MSRSGC defines six diagnostic fine-needle aspiration categories encompassing the spectrum of non-neoplastic, benign and malignant lesions of the salivary glands. The goal of the MSRSGC is to combine each diagnostic category with a defined risk of malignancy and a specific clinical and/or surgical management algorithm. Since its initial publication in 2018, more than 200 studies and commentaries have been published, confirming the role of the MSRSGC. The second edition of the MSRSGC, published in July 2023, includes refined risks of malignancy based on systematic reviews and meta-analyses, a new chapter summarising the use of salivary gland imaging, new advances in ancillary testing and updates in nomenclature.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 American Cancer Society, American Society of Cytopathology, and Wiley. Published by Elsevier Inc on behalf of American Society of Cytopathology and by Wiley on behalf of American Cancer Society. All rights reserved.
Références
Faquin WC, Powers CN. Salivary gland cytopathology. Essentials in Cytopathology Series. Vol 5. Springer; 2008. doi:10.4103/1742-6413
Jain R, Gupta R, Kudesia M, Singh S. Fine needle aspiration cytology in diagnosis of salivary gland lesions: a study with histologic comparison. Cytojournal. 2013;10:5.
Colella G, Cannavale R, Flamminio F, Foschini MP. Fine-needle aspiration cytology of salivary gland lesions: a systematic review. J Oral Maxillofac Surg. 2010;68(9):2146-2153. doi:10.1016/j.joms.2009.09.064
Schmidt RL, Hunt JP, Hall BJ, Wilson AR, Layfield LJ. A systematic review and meta-analysis of the diagnostic accuracy of frozen section for parotid gland lesions. Am J Clin Pathol. 2011;136(5):729-738. doi:10.1309/ajcp2sd8rfqeuzjw
Faquin WC, Rossi ED, Baloch Z, et al., eds. The Milan System for Reporting Salivary Gland Cytopathology. Springer; 2018.
El-Naggar AK, Chan J, Takata T, Grandis J, Blootweg P, eds. WHO Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Vol 9. 4th ed. IARC Press; 2022.
Geiger JL, Ismaila N, Beadle B, et al. Management of salivary gland malignancy: ASCO guideline. J Clin Oncol. 2021;39(17):1909-1941. doi:10.1200/jco.21.00449
Pusztaszeri M, Baloch Z, Vielh P, Faquin WC. Application of the Milan system for reporting risk stratification in salivary gland cytopathology. Cancer Cytopathol. 2018;126(1):69-70. doi:10.1002/cncy.21945
Pusztaszeri M, Rossi ED, Baloch ZW, Faquin WC. Salivary gland fine needle aspiration and introduction of the Milan reporting system. Adv Anat Pathol. 2019;26(2):84-92. doi:10.1097/pap.0000000000000224
Hughes JH, Volk EE, Wilbur DC, Cytopathology Resource Committee, College of American Pathologists. Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in nongynecologic cytology. Arch Pathol Lab Med. 2005;129(1):26-31. doi:10.5858/2005-129-26-pisgfc
Tyagi R, Dey P. Diagnostic problems of salivary gland tumors. Diagn Cytopathol. 2015;43(6):495-509. doi:10.1002/dc.23255
Wei S, Layfield L, LiVolsi VA, Montone KT, Baloch ZW. Reporting of fine needle aspiration (FNA) specimens of salivary gland lesions: a comprehensive review. Diagn Cytopathol. 2017;45(9):820-827. doi:10.1002/dc.23716
Johnson DN, Onenerk M, Krane J, et al. Cytologic grading of primary malignant salivary gland tumors: a blinded review by an international panel. Cancer Cytopathol. 2020;128(6):392-402. doi:10.1002/cncy.22271
Rossi ED, Faquin WC, Baloch Z, et al. The Milan System for Reporting Salivary Gland Cytopathology: analysis and suggestions of initial survey. Cancer Cytopathol. 2017;125(10):757-766. doi:10.1002/cncy.21898
Layfield LJ, Baloch ZW, Hirschowitz SL, Rossi ED. Impact on clinical follow-up of the Milan system for salivary gland cytology: a comparison with a traditional diagnostic classification. Cytopathology. 2018;29(4):335-342. doi:10.1111/cyt.12562
Rossi ED, Baloch Z, Pusztaszeri M, Faquin W. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an ASC-IAC-sponsored system for reporting salivary gland fine-needle aspiration. J Am Soc Cytopathol. 2018;7(3):111-118. doi:10.1159/000488969
Barbarite E, Puram SV, Derakhshan A, Rossi ED, Faquin WC, Varvares MA. A call for universal acceptance of the Milan System for Reporting Salivary Gland Cytopathology. Laryngoscope. 2020;130(1):80-85. doi:10.1002/lary.27905
Rossi ED, Faquin WC. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an international effort toward improved patient care-when the roots might be inspired by Leonardo da Vinci. Cancer Cytopathol. 2018;126(9):756-766. doi:10.1002/cncy.22040
Rossi ED, Wong LQ, Bizzarro T, et al. The impact of FNAC in the management of salivary gland lesions: institutional experiences leading to a risk-based classification scheme. Cancer Cytopathol. 2016;124(6):388-396. doi:10.1002/cncy.21710
Griffith CC, Pai RK, Schneider F, et al. Salivary gland tumor fine needle aspiration cytology. A proposal for a risk stratification classification. Am J Clin Pathol. 2015;143(6):839-853. doi:10.1309/ajcpmii6osd2hsja
Behaeghe M, Vander Poorten V, Hermans R, Politis C, Weynand B, Hauben E. The Milan System for Reporting Salivary Gland Cytopathology: single center experience with cell blocks. Diagn Cytopathol. 2020;48(11):972-978. doi:10.1002/dc.24515
Maleki Z, Miller JA, Arab SE, et al. “Suspicious” salivary gland FNA: risk of malignancy and interinstitutional variability. Cancer. 2018;126(2):94-100. doi:10.1002/cncy.21939
Viswanathan K, Sung S, Scognamiglio T, Yang GC, Siddiqui MT, Rao RA. The role of the Milan System for Reporting Salivary Gland Cytopathology: a 5-year institutional experience. Cancer Cytopathol. 2018;126(8):541-551. doi:10.1002/cncy.22016
Wang H, Malik A, Maleki Z, et al. “Atypical” salivary gland fine needle aspiration: risk of malignancy and interinstitutional variability. Diagn Cytopathol. 2017;45(12):1088-1094. doi:10.1002/dc.23826
Rohilla M, Singh P, Rajwanshi A, et al. Three-year cytohistological correlation of salivary gland FNA cytology at a tertiary center with the application of the Milan system for risk stratification. Cancer Cytopathol. 2017;125(10):767-775. doi:10.1002/cncy.21900
Thiryayi SA, Low YX, Shelton D, Narine N, Slater D, Rana DN. A retrospective 3-year study of salivary gland FNAC with categorisation using the Milan reporting system. Cytopathology. 2018;29(4):343-348. doi:10.1111/cyt.12557
Liu H, Ljungren C, Lin F, Zarka MA, Chen L. Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology. Cancer Cytopathol. 2018;126(7):490-497. doi:10.1002/cncy.22002
Rossi ED, Faquin WC. The Milan System for Reporting Salivary Gland Cytopathology: the clinical impact so far. Considerations from theory to practice. Cytopathology. 2020;31(3):181-184. doi:10.1111/cyt.12819
Jalaly JB, Farahani SJ, Baloch ZW. The Milan System for Reporting Salivary Gland Cytopathology: a comprehensive review of the literature. Diagn Cytopathol. 2020;48(10):880-889. doi:10.1002/dc.24536
Maleki Z, Baloch Z, Lu R, et al. Application of the Milan system for reporting submandibular gland cytopathology: an international, multi-institutional study. Cancer Cytopathol. 2019;127(5):306-315. doi:10.1002/cncy.22135
Lubin D, Buonocore D, Wei XJ, Cohen J, Lin O. The Milan system at Memorial Sloan Kettering: utility of the categorization system for in-house salivary gland fine-needle aspiration cytology at a comprehensive cancer center. Diagn Cytopathol. 2020;48(3):183-190. doi:10.1002/dc.24350
Kurtycz DFI, Rossi ED, Baloch Z, et al. Milan Interobserver Reproducibility Study (MIRST): Milan system 2018. J Am Soc Cytopathol. 2020;9(3):116-125. doi:10.1016/j.jasc.2019.12.002
Jo V, Krane J. Ancillary testing in salivary gland cytology: a practical guide. Cancer Cytopathol. 2018;126(Suppl 8):627-642. doi:10.1002/cncy.22010
Wong KS, Marino-Enriquez A, Hornick JL, Jo VY. NR4A3 immunohistochemistry reliably discriminates acinic cell carcinoma from mimics. Head Neck Pathol. 2021;15(2):425-432. doi:10.1007/s12105-020-01213-4
Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Gene Chromosome Cancer. 2007;46(7):708-715. doi:10.1002/gcc.20458
Parfitt JR, McLachlin CM, Weir MM. Comparison of ThinPrep and conventional smears in salivary gland fine-needle aspiration biopsies. Cancer. 2007;111(2):123-129. doi:10.1002/cncr.22575
Hashitani S, Urade M, Zushi Y, Segawa E, Okui S, Sakurai K. Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung. Oncol Rep. 2007;17(1):67-72. doi:10.3892/or.17.1.67
Winnes M, Enlund F, Mark J, Stenman G. The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucuepidermoid carcinoma? J Mol Diagn. 2006;8(3):394-395; author reply 395-396. doi:10.2353/jmoldx.2006.060020
Seethala RR, LiVolsi VA, Zhang PJ, Pasha TL, Baloch ZW. Comparison of p63 and p73 expression in benign and malignant salivary gland lesions. Head Neck. 2005;27(8):696-702. doi:10.1002/hed.20227
Chu PG, Lyda MH, Weiss LM. Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumours. Histopathology. 2001;39(1):9-16. doi:10.1046/j.1365-2559.2001.01105.x
Ruschenburg I, Korabiowska M, Schlott T, Kubitz A, Droese M. The value of PCR technique in fine needle aspiration biopsy of salivary gland for diagnosis of low-grade B-cell lymphoma. Int J Mol Med. 1998;2(3):339-341. doi:10.3892/ijmm.2.3.339
Moore JG, Bocklage T. Fine-needle aspiration biopsy of large-cell undifferentiated carcinoma of the salivary glands: presentation of two cases, literature review, and differential cytodiagnosis of high-grade salivary gland malignancies. Diagn Cytopathol. 1998;19(1):44-50. doi:10.1002/(sici)1097-0339(199807)19:1<44::aid-dc9>3.0.co;2-o
Andersson MK, Stenman G. The landscape of gene fusions and somatic mutations in salivary gland neoplasms-implications for diagnosis and therapy. Oral Oncol. 2016;57:63-69. doi:10.1016/j.oraloncology.2016.04.002
Weinreb I. Translocation-associated salivary gland tumors: a review and update. Adv Anat Pathol. 2013;20(6):367-377. doi:10.1097/pap.0b013e3182a92cc3
Pusztaszeri MP, García JJ, Faquin WC. Salivary gland FNA: new markers and new opportunities for improved diagnosis. Cancer Cytopathol. 2016;124(5):307-316. doi:10.1002/cncy.21649
Pusztaszeri MP, Faquin WC. Update in salivary gland cytopathology: recent molecular advances and diagnostic applications. Semin Diagn Pathol. 2015;32(4):264-274. doi:10.1053/j.semdp.2014.12.008
Griffith CC, Schmitt AC, Little JL, Magliocca KR. New developments in salivary gland pathology: clinically useful ancillary testing and new potentially targetable molecular alterations. Arch Pathol Lab Med. 2017;141(3):381-395. doi:10.5858/arpa.2016-0259-sa
Griffith CC, Siddiqui MT, Schmitt AC. Ancillary testing strategies in salivary gland aspiration cytology: a practical pattern-based approach. Diagn Cytopathol. 2017;45(9):808-819. doi:10.1002/dc.23715
Darras N, Mooney KL, Long SR. Diagnostic utility of fluorescence in situ hybridization testing on cytology cell blocks for the definitive classification of salivary gland neoplasms. J Am Soc Cytopathol. 2019;8(3):157-164. doi:10.1016/j.jasc.2019.01.006
Foo WC, Jo VY, Krane JF. Usefulness of translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms. Cancer Cytopathol. 2016;124(6):397-405. doi:10.1002/cncy.21693
Evrard SM, Meilleroux J, Daniel G, et al. Use of fluorescent in-situ hybridisation in salivary gland cytology: a powerful diagnostic tool. Cytopathology. 2017;28(4):312-320. doi:10.1111/cyt.12427
Hudson JB, Collins BT. MYB gene abnormalities t(6;9) in adenoid cystic carcinoma fine-needle aspiration biopsy using fluorescence in situ hybridization. Arch Pathol Lab Med. 2014;138(3):403-409. doi:10.5858/arpa.2012-0736-oa
Pusztaszeri MP, Sadow PM, Ushiku A, Bordignon P, McKee TA, Faquin WC. MYB immunostaining is a useful ancillary test for distinguishing adenoid cystic carcinoma from pleomorphic adenoma in fine-needle aspiration biopsy specimens. Cancer Cytopathol. 2014;122(4):257-265. doi:10.1002/cncy.21381
Moon A, Cohen C, Siddiqui MT. MYB expression: potential role in separating adenoid cystic carcinoma (ACC) from pleomorphic adenoma (PA). Diagn Cytopathol. 2016;44(10):799-804. doi:10.1002/dc.23551
Xu B, Haroon Al Rasheed MR, Antonescu CR, et al. Pan-Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6-NTRK3 fusion. Histopathology. 2020;76(3):375-382. doi:10.1111/his.13981
Skaugen JM, Seethala RR, Chiosea SI, Landau MS. Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma. Cancer Cytopathol. 2021;129(2):104-113. doi:10.1002/cncy.22338
Freiberger SN, Brada M, Fritz C, et al. SalvGlandDx-a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets. Neoplasia. 2021;23(5):473-487. doi:10.1016/j.neo.2021.03.008
Stacchini A, Aliberti S, Pacchioni D, et al. Flow cytometry significantly improves the diagnostic value of fine needle aspiration cytology of lymphoproliferative lesions of salivary glands. Cytopathology. 2014;25(4):231-240. doi:10.1111/cyt.12084
Taverna C, Baněčková M, Lorenzon M, et al. MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics. Histopathology. 2021;79(3):315-324. doi:10.1111/his.14251
Rooper L, Sharma R, Bishop JA. Polymorphous low grade adenocarcinoma has a consistent p63+/p40− immunophenotype that helps distinguish it from adenoid cystic carcinoma and cellular pleomorphic adenoma. Head Neck Pathol. 2015;9(1):79-84. doi:10.1007/s12105-014-0554-4
Hsieh MS, Lee YH, Chang YL. SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. Hum Pathol. 2016;56:134-142. doi:10.1016/j.humpath.2016.05.021
Mito JK, Jo VY, Chiosea SI, Dal Cin P, Krane JF. HMGA2 is a specific immunohistochemical marker for pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. Histopathology. 2017;71(4):511-521. doi:10.1111/his.13246
Rooper LM, Lombardo KA, Oliai BR, Ha PK, Bishop JA. MYB RNA in situ hybridization facilitates sensitive and specific diagnosis of adenoid cystic carcinoma regardless of translocation status. Am J Surg Pathol. 2021;45(4):488-497. doi:10.1097/pas.0000000000001616
Mino M, Pilch BZ, Faquin WC. Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker for adenoid cystic carcinoma. Mod Pathol. 2003;16(12):1224-1231. doi:10.1097/01.mp.0000096046.42833.c7
Jo VY, Sholl LM, Krane JF. Distinctive patterns of CTNNB1 (β-catenin) alterations in salivary gland basal cell adenoma and basal cell adenocarcinoma. Am J Surg Pathol. 2016;40(8):1143-1150. doi:10.1097/pas.0000000000000669
Schmitt AC, Griffith CC, Cohen C, Siddiqui MT. LEF-1: diagnostic utility in distinguishing basaloid neoplasms of the salivary gland. Diagn Cytopathol. 2017;45(12):1078-1083. doi:10.1002/dc.23820
Schmitt AC, McCormick R, Cohen C, Siddiqui MT. DOG1, p63, and S100 protein: a novel immunohistochemical panel in the differential diagnosis of oncocytic salivary gland neoplasms in fine-needle aspiration cell blocks. J Am Soc Cytopathol. 2014;3(6):303-308. doi:10.1016/j.jasc.2014.06.001
Schmitt AC, Cohen C, Siddiqui MT. Expression of SOX10 in salivary gland oncocytic neoplasms: a review and a comparative analysis with other immunohistochemical markers. Acta Cytol. 2015;59(5):384-390. doi:10.1159/000441890
Nakaguro M, Tanigawa M, Hirai H, et al. The diagnostic utility of RAS Q61R mutation-specific immunohistochemistry in epithelial-myoepithelial carcinoma. Am J Surg Pathol. 2021;45:885-894. doi:10.1097/pas.0000000000001673
Pisapia P, Pepe F, Sgariglia R, et al. Next generation sequencing in cytology. Cytopathology. 2021;32(5):588-595. doi:10.1111/cyt.12974