Ultra-widefield-guided swept-source optical coherence tomography findings of peripheral vitreoretinal abnormality in young myopes.

To evaluate the ultra-widefield fundus photography (UWF-FP)-guided swept-source optical coherence tomography (SS-OCT) images of peripheral vitreoretinal abnormality (PVRA) in young asymptomatic myopes. Cross-sectional, single-center study. 1,966 eyes of 983 consecutive patients aged 18-42 years with refractive error in the spherical equivalent of <0 diopters who visited KEYE Eye Center, Seoul, Republic of Korea, for refractive surgery. The prevalence of PVRA and their characteristics, including shape, location, presence of pigmentation, membrane, retinal breaks and detachment, were evaluated. A logistic regression analysis was done to evaluate the risk factors of PVRA and the risk of retinal breaks or detachment among patients with PVRA eyes. The incidence and risk factors for PVRA and for retinal breaks or detachment. Among 1,966 eyes, 317 (16.1%) eyes had PVRA; 182 (57.4%) and 135 (42.6%) eyes had focal and linear lesions, respectively. The risk of PVRA was increased with axial length of the eyes (OR: 1.238, 95%CI: 1.112-1.379, P<0.001), corneal astigmatism (OR:1.320, 95%CI: 1.148-1.519, P<0.001), presence of discrete margins of different retinal reflectivity (DMDRR; indicating outer retinal disruption from abnormal vitreoretinal traction) (OR: 1.751, 95%CI: 1.334-2.300, P<0.001), and posterior vitreous detachment (PVD) at posterior pole of the retina (OR: 1.833, 95%CI: 1.352-2.485, P<0.001). Among eyes with PVRA, patient age (OR: 1.063, 95%CI: 1.008-1.121, P=0.025), linear (OR: 15.234, 95%CI: 7.891-29.407, P<0.001) and multiple lesions (OR: 3.432, 95%CI: 1.780-6.620, P<0.001) were independently associated with the presence of retinal breaks or detachment. The follow-up for PVRA among young myopes should be personalized based on their ocular characteristics, including asymmetric ocular expansion and vitreoretinal interface status. The treatment plan for PVRA eyes should emphasize the greater risk of retinal breaks and detachment with increasing age and the presence of linear and multiple lesions.

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