The Modified Fels and Abbreviated Modified Fels Knee Skeletal-Maturity Systems in the Prediction of Leg-Length Discrepancy.


Journal

The Journal of bone and joint surgery. American volume
ISSN: 1535-1386
Titre abrégé: J Bone Joint Surg Am
Pays: United States
ID NLM: 0014030

Informations de publication

Date de publication:
16 Nov 2023
Historique:
received: 11 03 2023
accepted: 31 08 2023
medline: 17 11 2023
pubmed: 17 11 2023
entrez: 16 11 2023
Statut: aheadofprint

Résumé

The Modified Fels (mFels) and Abbreviated Modified Fels (abFels) knee systems have been recently developed as options for grading skeletal maturity without the need for a separate hand radiograph. We sought to determine the interobserver reliability of these systems and to compare their prediction accuracy with that of the Greulich and Pyle (G-P) atlas in a cohort managed with epiphysiodesis for leg-length discrepancy (LLD). Three reviewers scored 20 knee radiographs using the mFels system, which includes 5 qualitative and 2 quantitative measures as well as a quantitative output. Short leg length (SL), long leg length (LL), and LLD prediction errors at maturity using the White-Menelaus (W-M) method and G-P, mFels, or abFels skeletal age were compared in a cohort of 60 patients managed with epiphysiodesis for LLD. Intraclass correlation coefficients for the 2 quantitative variables and the quantitative output of the mFels system using 20 knee radiographs ranged from 0.55 to 0.98, and kappa coefficients for the 5 qualitative variables ranged from 0.56 to 1, indicating a reliability range from moderate to excellent. In the epiphysiodesis cohort, G-P skeletal age was on average 0.25 year older than mFels and abFels skeletal ages, most notably in females. The majority of average prediction errors between G-P, mFels, and abFels were <0.5 cm, with the greatest error being for the SL prediction in females, which approached 1 cm. Skeletal-age estimates with the mFels and abFels systems were statistically comparable. The mFels skeletal-age system is a reproducible method of determining skeletal age. Prediction errors in mFels and abFels skeletal ages were clinically comparable with those in G-P skeletal ages in this epiphysiodesis cohort. Further work is warranted to optimize and validate the accuracy of mFels and abFels skeletal ages to predict LLD and the impact of epiphysiodesis, particularly in females. Both the mFels and abFels systems are promising means of estimating skeletal age, avoiding additional radiation and health-care expenditure. Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

Sections du résumé

BACKGROUND BACKGROUND
The Modified Fels (mFels) and Abbreviated Modified Fels (abFels) knee systems have been recently developed as options for grading skeletal maturity without the need for a separate hand radiograph. We sought to determine the interobserver reliability of these systems and to compare their prediction accuracy with that of the Greulich and Pyle (G-P) atlas in a cohort managed with epiphysiodesis for leg-length discrepancy (LLD).
METHODS METHODS
Three reviewers scored 20 knee radiographs using the mFels system, which includes 5 qualitative and 2 quantitative measures as well as a quantitative output. Short leg length (SL), long leg length (LL), and LLD prediction errors at maturity using the White-Menelaus (W-M) method and G-P, mFels, or abFels skeletal age were compared in a cohort of 60 patients managed with epiphysiodesis for LLD.
RESULTS RESULTS
Intraclass correlation coefficients for the 2 quantitative variables and the quantitative output of the mFels system using 20 knee radiographs ranged from 0.55 to 0.98, and kappa coefficients for the 5 qualitative variables ranged from 0.56 to 1, indicating a reliability range from moderate to excellent. In the epiphysiodesis cohort, G-P skeletal age was on average 0.25 year older than mFels and abFels skeletal ages, most notably in females. The majority of average prediction errors between G-P, mFels, and abFels were <0.5 cm, with the greatest error being for the SL prediction in females, which approached 1 cm. Skeletal-age estimates with the mFels and abFels systems were statistically comparable.
CONCLUSIONS CONCLUSIONS
The mFels skeletal-age system is a reproducible method of determining skeletal age. Prediction errors in mFels and abFels skeletal ages were clinically comparable with those in G-P skeletal ages in this epiphysiodesis cohort. Further work is warranted to optimize and validate the accuracy of mFels and abFels skeletal ages to predict LLD and the impact of epiphysiodesis, particularly in females. Both the mFels and abFels systems are promising means of estimating skeletal age, avoiding additional radiation and health-care expenditure.
LEVEL OF EVIDENCE METHODS
Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

Identifiants

pubmed: 37972990
doi: 10.2106/JBJS.23.00286
pii: 00004623-990000000-00948
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 by The Journal of Bone and Joint Surgery, Incorporated.

Déclaration de conflit d'intérêts

Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJS/H760).

Références

Greulich WW, Pyle SI. Radiographic Atlas of Skeletal Development of the Hand and Wrist. 2nd ed. Palo Alto: Stanford University Press; 1959.
Alshamrani K, Messina F, Offiah AC. Is the Greulich and Pyle atlas applicable to all ethnicities? A systematic review and meta-analysis. Eur Radiol. 2019 Jun;29(6):2910-23.
Satoh M. Bone age: assessment methods and clinical applications. Clin Pediatr Endocrinol. 2015 Oct;24(4):143-52.
Bull RK, Edwards PD, Kemp PM, Fry S, Hughes IA. Bone age assessment: a large scale comparison of the Greulich and Pyle, and Tanner and Whitehouse (TW2) methods. Arch Dis Child. 1999 Aug;81(2):172-3.
Furdock RJ, Kuo A, Chen KJ, Benedick AJ, Liu RW. Applicability of the Modified Fels and Optimized Oxford Skeletal Maturity Estimation Systems to the Modern Pediatric Population. J Pediatr Orthop. 2023 Mar 1;43(3):e254-9.
Makarov MR, Jackson TJ, Smith CM, Jo CH, Birch JG. Timing of Epiphysiodesis to Correct Leg-Length Discrepancy: A Comparison of Prediction Methods. J Bone Joint Surg Am. 2018 Jul 18;100(14):1217-22.
Roche AF. Growth, Maturation, and Body Composition: The Fels Longitudinal Study 1929–1991. Cambridge: Cambridge University Press; 1992.
Roche AF, Wainer H, Thissen D. Skeletal maturity: the knee joint as a biological indicator. New York: Plenum Medical Book; 1975.
Pyle SI, Hoerr NL. Radiographic Atlas of Skeletal Development of the Knee: A Standard of Reference. Springfield: Charles C Thomas; 1955.
Benedick A, Knapik DM, Duren DL, Sanders JO, Cooperman DR, Lin FC, Liu RW. Systematic isolation of key parameters for estimating skeletal maturity on knee radiographs. J Bone Joint Surg Am. 2021 May 5;103(9):795-802.
Furdock RJ, Cho E, Benedick AJ, Yu J, Sattar A, Liu RW. The utility of the modified Fels knee skeletal maturity system in limb length prediction. J Pediatr Orthop. 2022 Jul 1;42(6):327-34.
Castillo Tafur JC, Benedick A, Knapik DM, Janes JL, Delozier SJ, Liu RW. Skeletal Maturity Using Knee X-rays: Understanding the Resilience of 7 Radiographic Parameters to Rotational Position. J Pediatr Orthop. 2021 Oct 1;41(9):e733-8.
Yuan JT, Furdock RJ, Benedick A, Liu RW. Estimating Skeletal Maturity by Segmented Linear Modeling of Key AP Knee Radiographic Parameters. J Pediatr Orthop. 2022 Mar 1;42(3):169-73.
Anderson M, Green WT, Messner MB. Growth and predictions of growth in the lower extremities. J Bone Joint Surg Am. 1963 Jan;45-A:1-14.
Anderson M, Messner MB, Green WT. Distribution of lengths of the normal femur and tibia in children from one to eighteen years of age. J Bone Joint Surg Am. 1964 Sep;46:1197-202.
Beumer A, Lampe HI, Swierstra BA, Diepstraten AF, Mulder PG. The straight line graph in limb length inequality. A new design based on 182 Dutch children. Acta Orthop Scand. 1997 Aug;68(4):355-60.
Paley D, Bhave A, Herzenberg JE, Bowen JR. Multiplier method for predicting limb-length discrepancy. J Bone Joint Surg Am. 2000 Oct;82(10):1432-46.
White JW, Stubbins SG. Growth arrest for equalizing leg lengths. JAMA. 1944;126(18):1146-9.
Menelaus MB. Correction of leg length discrepancy by epiphysial arrest. J Bone Joint Surg Br. 1966 May;48(2):336-9.
Westh RN, Menelaus MB. A simple calculation for the timing of epiphysial arrest: a further report. J Bone Joint Surg Br. 1981 Feb;63-B(1):117-9.
Kluck DG, Makarov MR, Kanaan Y, Jo CH, Birch JG. Comparison of “Human” and Artificial Intelligence Hand-and-Wrist Skeletal Age Estimation in an Epiphysiodesis Cohort. J Bone Joint Surg Am. 2023 Feb 1;105(3):202-6.
Boeyer ME, Sherwood RJ, Deroche CB, Duren DL. Early Maturity as the New Normal: A Century-long Study of Bone Age. Clin Orthop Relat Res. 2018 Nov;476(11):2112-22.
King DG, Steventon DM, O’Sullivan MP, Cook AM, Hornsby VP, Jefferson IG, King PR. Reproducibility of bone ages when performed by radiology registrars: an audit of Tanner and Whitehouse II versus Greulich and Pyle methods. Br J Radiol. 1994 Sep;67(801):848-51.
Sanders JO, Qiu X, Lu X, Duren DL, Liu RW, Dang D, Menendez ME, Hans SD, Weber DR, Cooperman DR. The Uniform Pattern of Growth and Skeletal Maturation during the Human Adolescent Growth Spurt. Sci Rep. 2017 Dec 1;7(1):16705.
Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, Hasemeier CM. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics. 1997 Apr;99(4):505-12.
Herman-Giddens ME, Steffes J, Harris D, Slora E, Hussey M, Dowshen SA, Wasserman R, Serwint JR, Smitherman L, Reiter EO. Secondary sexual characteristics in boys: data from the Pediatric Research in Office Settings Network. Pediatrics. 2012 Nov;130(5):e1058-68.
Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME. Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics. 2001 Aug;108(2):347-53

Auteurs

Dylan G Kluck (DG)

Department of Orthopaedic Surgery and Sports Medicine, Shriners Children's Lexington, University of Kentucky, Lexington, Kentucky.

Marina R Makarov (MR)

Texas Scottish Rite Hospital for Children, Dallas, Texas.

David A Podeszwa (DA)

Texas Scottish Rite Hospital for Children, Dallas, Texas.

Ryan J Furdock (RJ)

Department of Orthopedics, University Hospital Cleveland Medical Center, Cleveland, Ohio.

Raymond W Liu (RW)

Rainbow Babies and Children's Hospital, Cleveland, Ohio.

Chan-Hee Jo (CH)

Texas Scottish Rite Hospital for Children, Dallas, Texas.

John G Birch (JG)

Texas Scottish Rite Hospital for Children, Dallas, Texas.

Classifications MeSH