Genome-wide analysis of lectins in cyanobacteria: from evolutionary mode to motif patterns.
Cyanobacteria
Evolution
Gene family
Lectin
Motif
Journal
BMC genomics
ISSN: 1471-2164
Titre abrégé: BMC Genomics
Pays: England
ID NLM: 100965258
Informations de publication
Date de publication:
16 Nov 2023
16 Nov 2023
Historique:
received:
26
03
2023
accepted:
06
11
2023
medline:
27
11
2023
pubmed:
17
11
2023
entrez:
17
11
2023
Statut:
epublish
Résumé
Lectins are glycoproteins that can bind to specific carbohydrates, and different lectin families exhibit different biological activities. They are also present in the cyanobacteria and many of them have shown excellent therapeutic effect, which deserve for bioprospecting. However, in comparison to those from terrestrial plants, the current knowledge on cyanobacterial lectins is very limited. To this end, genome-wide analyses were performed to find out their evolutionary mode and motif patterns in 316 genomes of representative taxa. In results, 196 putative cyanobacterial lectins were dig out and 105 of them were classified into known families. Seven lectins were found to be belonged to distinct two lectin families, and they may have the potential activities of both lectin families. Whereas no MFP-2, Chitin, and Nictaba family lectins were found. What's more, the Legume lectin-like lectin family was found to be the richest and most complex in cyanobacteria, which could be a main research direction for future cyanobacterial lectin bioprospecting and development. Our classification and prediction of cyanobacteria lectins is expected to provide assistance in the development of lectin-based medicine and provide solutions to the current thorny viral and tumor diseases in humans.
Identifiants
pubmed: 37974077
doi: 10.1186/s12864-023-09790-8
pii: 10.1186/s12864-023-09790-8
pmc: PMC10655256
doi:
Substances chimiques
Lectins
0
Glycoproteins
0
Plant Lectins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
688Subventions
Organisme : National Key Research and Development Program
ID : 2018YFA0903000
Organisme : National Key Research and Development Program
ID : 2018YFA0903000
Organisme : National Key Research and Development Program
ID : 2018YFA0903000
Organisme : National Key Research and Development Program
ID : 2018YFA0903000
Organisme : National Basic Science Data Center
ID : NBSDC-DB-22
Organisme : National Basic Science Data Center
ID : NBSDC-DB-22
Organisme : National Basic Science Data Center
ID : NBSDC-DB-22
Organisme : National Basic Science Data Center
ID : NBSDC-DB-22
Informations de copyright
© 2023. The Author(s).
Références
Int J Biol Macromol. 2018 Feb;107(Pt A):1320-1329
pubmed: 28970169
Future Med Chem. 2014;6(18):2113-29
pubmed: 25531972
J Am Chem Soc. 2009 Nov 18;131(45):16500-8
pubmed: 19856962
Biomolecules. 2021 Mar 22;11(3):
pubmed: 33810129
Proc Int Conf Intell Syst Mol Biol. 1994;2:28-36
pubmed: 7584402
J Nat Med. 2021 Jan;75(1):223-231
pubmed: 33025357
Mar Drugs. 2019 Oct 06;17(10):
pubmed: 31590428
Mar Biotechnol (NY). 2016 Feb;18(1):144-60
pubmed: 26593063
Mol Biol Evol. 2020 May 1;37(5):1530-1534
pubmed: 32011700
Biochem Biophys Res Commun. 2011 Feb 11;405(2):291-6
pubmed: 21219864
Plant Physiol Biochem. 2016 Nov;108:165-176
pubmed: 27434144
J Biol Chem. 2007 Apr 13;282(15):11021-9
pubmed: 17314091
Mar Drugs. 2019 Jul 26;17(8):
pubmed: 31357490
Mar Drugs. 2021 Dec 01;19(12):
pubmed: 34940686
Biochimie. 2022 Nov;202:136-145
pubmed: 35952948
Plant Genome. 2017 Jul;10(2):
pubmed: 28724081
Front Plant Sci. 2019 Jan 29;10:36
pubmed: 30761173
Crit Rev Microbiol. 2015 Feb;41(1):77-88
pubmed: 23855360
Ann Clin Lab Sci. 2022 May;52(3):511-525
pubmed: 35777803
Front Cell Infect Microbiol. 2022 Sep 23;12:990875
pubmed: 36211961
Nucleic Acids Res. 2021 Jan 8;49(D1):D1548-D1554
pubmed: 33174598
Int J Biol Macromol. 2017 Sep;102:475-496
pubmed: 28437766
Mar Drugs. 2015 May 29;13(6):3454-65
pubmed: 26035023